Project Grant R44HL158452

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), totals $827,682 and is effective from July 29, 2024 through June 30, 2029. The award aims to develop comprehensive imaging approaches to characterize lung perfusion and guide treatment for Acute Respiratory Distress Syndrome (ARDS), a life-threatening condition that is a leading cause of death from COVID-19. The project will leverage...

This Project Grant award, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to optimize the image quality of mobile photon-counting CT (PCCT) scanners for use in the neuro intensive care unit (ICU). The $1,344,298 award to The General Hospital Corporation (Massachusetts General Hospital) will leverage the benefits of FDA-approved mobile PCCT...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, provides $144,989 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop and test deep generative models using computed tomography (CT) images to predict lung injury progression and treatment responses for patients with acute respiratory distress syndrome (ARDS). The primary objectives are to: 1)...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), provides $268,500 to Brigham & Women's Hospital Inc. to develop and validate a quantitative marker of pulmonary microvascular injury using AI-based analysis of non-contrast CT scans. The research aims to explore the correlation between microvascular volume loss and the longitudinal progression of chronic obstructive pulmonary...

This $2,000,000 Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) will enable The University of Iowa to upgrade its existing research CT scanner to a state-of-the-art photon-counting CT scanner (Siemens NAEOTOM Alpha). The new scanner will significantly enhance the university's ability to conduct advanced quantitative lung imaging research across multiple disease areas, including COPD, asthma, IPF, and long COVID. Key benefits of...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to demonstrate the feasibility of using Lung Quantitative Ultrasound (LQUS) for assessing the severity of pulmonary edema due to heart failure and idiopathic pulmonary fibrosis. The $666,609 award to North Carolina State University will develop new LQUS-based metrics to monitor chronic lung conditions in real-time, in-vivo, and...

This federal Project Grant award for $608,944 was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286). The goal is to develop an AI-assisted strategy for monitoring pulmonary congestion in acute heart failure patients in emergency settings. The project aims to automate lung ultrasound (LUS) congestion scoring using AI/ML methods and a...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $183,388 to the Regents of the University of Michigan to conduct research on defining and characterizing the clinical syndrome of combined pulmonary fibrosis and emphysema (CPFE) using quantitative CT imaging. The primary objectives are to (1) define CPFE through quantitative imaging methodologies, and (2) compare patient...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to develop an imaging-compatible pre-clinical ex vivo lung perfusion (EVLP) system. The goal is to obtain structural, functional, and metabolic biomarkers for assessing donor lung health, in order to optimize EVLP parameters and recondition lungs with common defects like atelectasis, ventilator-induced lung injury, and...

This Project Grant award, with a total funding amount of $626,247, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant aims to develop a tool that can leverage quantitative imaging data from lung cancer screening to identify individuals at risk for chronic obstructive pulmonary disease (COPD), which is the third leading cause of death globally. The key products and services to be delivered...