Project Grant R44HL145937

This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $161,500.00 to the University of Virginia to conduct research aimed at understanding the molecular mechanisms of heterotaxy, a severe form of congenital heart disease (CHD). The research seeks to uncover the genetic pathogenesis of CHD, which affects nearly 1 in 100 live-born infants, in order to improve...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will develop high-throughput functional assays to assess genomic variants in JAG1 and NOTCH2 genes associated with Alagille syndrome. The $656,679 award to The Children's Hospital of Philadelphia will create multiplexed assays to evaluate the impact of over 10,000 variants on protein expression...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,727,892 to the University of Massachusetts Medical School (UMass Medical) to study the role of the RASA1 gene in embryonic development, particularly in relation to vascular and lymphatic anomalies. The key objectives of this 5-year research project are to: 1) define the cellular and molecular...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $487,567 to Indiana University to conduct integrative genomic analysis and develop high-dimensional risk prediction models for congenital heart defects (CHDs). The research aims to identify genetic variants and biological pathways associated with CHDs, as well as build predictive models leveraging genetic, epigenetic,...

This $707,218 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will develop a new approach for secondary fetal screening using 0.55T MRI technology. The project aims to assess the potential of lower-field MRI to serve as an alternative to ultrasound for fetal screening in high-risk pregnancies with poor acoustic windows, compare the image quality and diagnostic performance of 0.55T MRI...

This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $757,089 to support research aimed at identifying novel genes and variants associated with congenital diaphragmatic hernia (CDH) and validating these discoveries in mouse models. The key objectives are to leverage genomic data from CDH patient cohorts to identify novel CDH-associated genes and variants, and then use a...

This $153,252 project grant was awarded on September 9, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant aims to develop new strategies to identify candidate individuals for early genetic therapies. The key products or services to be delivered include: 1) Reevaluating guidelines for universal preconception carrier screening to improve uptake of genetic testing, using data...

This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to improve the identification of genetic contributors to rare diseases, particularly neurodevelopmental disorders in children. The $1,802,392 award will fund the sequencing of 900 genomes, including 500 affected individuals and 200 of their parents, using Pacific Biosciences'...

This $223,224 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to understand how altered brain connectivity in children with congenital heart disease (CHD) impacts their developmental outcomes and executive function. The research, conducted by the Children's Hospital Corporation (dba Boston Children's Hospital), will leverage two cohorts of...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), CFDA Program #93.350, provides funding of $489,500 to The Children's Hospital of Philadelphia (CHOP) Research Institute to conduct research on a potential treatment for Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM). The research aims to study the effects of a small compound called Repsox on correcting the platelet defects and reducing the risk of leukemic transformation in...