Project Grant R44HL134532

This Project Grant award for $691,708.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports the development of a novel contrast-free ultrasound-based quantitative angio flow imaging technique to assess peripheral arterial disease (PAD) of the lower limbs. The research project aims to determine the efficacy of this new "Angio Flow Reactivity Analysis" (AFRA) method for assessing PAD in patient...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $3,717,718 Cooperative Agreement under the Cardiovascular Diseases Research program (CFDA 93.837) to Duke University to conduct the "LOW DOSE COLCHICINE IN PATIENTS WITH PERIPHERAL ARTERY DISEASE TO ASSESS RESIDUAL VASCULAR RISK (LEADER-PAD)" clinical trial. This 4-year study, starting on September 25, 2024, aims to enroll 1,000 U.S. participants as part of a larger 6,150-patient international trial. The trial will...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $150,000 to the University of Texas at Austin to develop a biomechanics-guided wireless ultrasonic e-tattoo sensor system for continuous, cuffless ambulatory blood pressure monitoring. The key objectives are to: 1) Design an ultra-low-power, millimeter-scale application-specific integrated circuit (ASIC) capable of duplex mode ultrasound...

Dynocardia Inc. received a $256,000 National Science Foundation Project Grant to advance development of a novel continuous, cuffless blood pressure monitoring device. Funded through the NSF Engineering Directorate's SBIR program, the award will support Dynocardia's efforts to address motion artifacts and enable accurate, beat-to-beat blood pressure measurements in hospital intensive care and operating room settings. Accurate 24-hour blood pressure monitoring has potential to significantly...

Vivonics Inc., a medical technology company based in Massachusetts, received a $331,455 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a near-infrared layered imaging system called NIR-LITH. This system aims to provide objective, three-dimensional hemodynamic mapping of diabetic foot ulcers and surrounding tissue with 1 mm depth resolution, improving clinicians' ability to assess wound healing potential and make more accurate...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $295,895 to Ricovr Healthcare Inc. to develop a rapid, low-cost, point-of-care (POC) diagnostic platform for quantitative measurement of placental growth factor (PlGF) to predict and detect pre-eclampsia. The goal is to create an objective, affordable POC tool to improve the clinical diagnosis and monitoring of pre-eclampsia, which...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) totaling $687,517 will support research at the University of Alabama at Birmingham (UAB) to elucidate the relationship between the gene Leiomodin1 (LMOD1) and peripheral artery disease (PAD). The key objectives are to: Use cell culture models and translational approaches to determine the mechanistic pathway by which reduced LMOD1 mediates impaired neovessel...

This $205,000 project grant from the National Institutes of Health's National Institute on Aging will fund research into the pathomechanics of diabetic foot ulcers at The University of Texas Southwestern Medical Center over a 12-month period. The research aims to identify more accurate markers and marker combinations for foot ulceration risk in patients with diabetic neuropathy and a history of prior ulcers. Using specialized equipment, the study will quantify two primary ulcer-causing...

This $254,369 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) aims to develop a wearable device capable of continuously sensing physiological signals for use in biometric authentication and health monitoring. The project, titled "Collaborative Research: Novel Robust Continuous Time-Efficient Biometric Profiling and Authentication Using Multispectral Photoplethysmography," will investigate the use of multispectral photoplethysmography (PPG)...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $425,176 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Eden Medical, Inc. to develop the "Smart Foot Mat" (SFM). The SFM is an in-home appliance designed to help prevent diabetic foot complications by allowing diabetic patients to monitor their foot oximetry and temperature on a daily basis. The grant funding will support the development of this novel...