Project Grant R44HL134456

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

This Project Grant, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a unique antimicrobial vascular catheter to prevent catheter-related bloodstream infections (CRBSI). The $272,702 award, effective September 1, 2023, with a completion date of February 29, 2024, will support research and development efforts to create an intravascular catheter with inherent long-lasting antiseptic properties. The...

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project grant, awarded to Materialize Bio, Inc. in Somerville, MA, aims to advance the development of bioengineered, next-generation tympanostomy tubes using innovative natural biopolymers like silk and chitosan. The $274,999 project, running from September 2024 to August 2025, focuses on a novel manufacturing approach utilizing 3D printed molds,...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,013,000 Project Grant to Endolynx Inc. to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT). The goal of this SBIR Phase I project is to demonstrate the feasibility of the OS-ETT, which aims to reduce the risk and incidence of esophageal intubation and unintended extubation during the over 30 million intubations performed annually in the U.S. The OS-ETT...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $571,410 to Pharynvac Surgical Technology Inc. to develop a novel device called "Pharynvac" that can mitigate key issues in sinonasal surgeries. Specifically, the Pharynvac device aims to reduce surgical staff exposure to pathogens and toxins, prevent...

This federal Project Grant award of $790,738, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop and evaluate the Thoraflush, a proactive clot-preventing cardiac chest tube that utilizes dual irrigation technology to maintain drainage patency. The key objectives are to: 1) Optimize the Thoraflush's efficacy in maintaining drainage patency using an in vitro mediastinum blood coagulation model, and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant awarded $274,440 to Vine Medical Inc., a for-profit manufacturing company, to develop a proof-of-concept for a self-deploying endotracheal intubation device. The proposed soft robotics system aims to achieve over a 90% first-pass intubation success rate, which would improve patient outcomes and reduce complications during emergency airway management procedures. The device is designed to...

This federal Project Grant award of $313,365.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and test a novel articulating stylet device called the SmartStylet. The device is designed to improve first-pass success rates for endotracheal intubation, a critical medical procedure, by allowing real-time adjustment of the stylet's curvature to match the patient's airway anatomy. The proposed work under this...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $842,408 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Inspire RX LLC, a start-up company based in Ann Arbor, Michigan. The goal of this 18-month project is to refine and further evaluate Inspire RX's "Aerosolve Biohelmet", a personal negative pressure device capable of preventing the spread of aerosolized pathogens while enabling non-invasive oxygen therapies for patients with highly...