Project Grant R44HL126469

This National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I award to RT Microdx Inc. provides $274,362 to develop a novel molecular diagnostic platform for detecting respiratory diseases like strep throat. The platform aims to provide laboratory-quality accuracy for at-home use by non-healthcare professionals. Key technical objectives include optimizing the sensitivity of the platform's pH-sensitive polymer detection mechanism and ensuring robust performance at...

This Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of an unbiased pulse-oximetry method to address documented skin-tone bias in conventional oxygen saturation measurements. Obligating $134,537 with a performance period from September 5, 2025, through June 30, 2030, the award funds research conducted by Trustees of Tufts College in Medford, Massachusetts. The research...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award for $997,142 aims to develop a rapid phenylalanine blood level monitor for patients with phenylketonuria (PKU), a lifelong genetic disorder. The product consists of a test strip and device that can provide frequent, accessible monitoring of phenylalanine levels from a finger prick to improve disease management and patient outcomes. The project focuses on optimizing the...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $297,587 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to General Fluidics Corporation to validate the performance of the AXESS system, a novel point-of-need clinical chemistry and hematology platform. The goal is to demonstrate equivalence between the AXESS system's results and those obtained from standard venous blood testing for a basic metabolic panel and complete blood count, using matched capillary and...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $238,500 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to the University of California, San Diego (UCSD) to develop a novel electrochemical lateral flow assay (ELFA) for diagnosing tuberculosis (TB) from a single drop of blood. The objective is to create a highly sensitive and specific point-of-need TB detection test that can accurately distinguish active TB from...

North Dakota State University will develop a point-of-care biosensor device for early detection of pancreatic cancer under a $278,820 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (NSF TIP, CFDA 47.084). The university aims to efficiently and accurately detect circulating microRNA biomarkers that have been linked to early pancreatic cancer using an electric field-based, fluorescent disposable sensor. If successful, the sensors could rapidly...

Grant Award Summary Analytical Diagnostic Solutions Inc. received a $305,352 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective July 1, 2025, through June 30, 2026. The company is developing HCY NOW, a quantitative point-of-care device for home-based monitoring of total blood homocysteine (THCy) levels to improve management of homocystinurias (HCUs)—inherited metabolic disorders characterized by plasma homocysteine accumulation. The...

This $550,000 Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of a non-invasive, multiplex blood test for the early detection of preeclampsia, a serious pregnancy complication. The project aims to advance the detection of vascular dysfunction, particularly preeclampsia, by optimizing a blood test that targets disease-inducing signaling proteins on the surface of...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support the development of a novel universal rapid test for HIV diagnosis. IGE Immunodiagnostics & Therapeutics, LLC, a minority-owned small business, will receive $294,948 to adapt their existing HIV ELISA test into a 5th generation antigen/antibody combination rapid test format. The goal is to create a simple, rapid,...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $269,922 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Steth X Microsystems Inc. to develop a smart, wearable contact microphone patch for extended and remote monitoring of lung functions. The goal is to create a low-profile, battery-powered wireless device capable of accurately detecting and quantifying adventitious lung sounds as well as breathing abnormalities in patients with respiratory...