Project Grant R44HL079701

Federal Project Grant Award Summary Boston Children's Hospital received a $178,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 15, 2025, with completion scheduled for June 14, 2026. The grant supports the development of a bone marrow organoid system to study RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM), a rare genetic disorder characterized by germline heterozygous loss-of-function...

Summary Yale University received a $644,061 Project Grant awarded August 25, 2025, from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports a research initiative investigating platelet dysfunction in pediatric multiple organ dysfunction syndrome (MODS), with focus on the role of endoplasmic reticulum stress and unfolded protein response mechanisms. The project, with a completion...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia Research Institute a $445,000 project grant effective July 1, 2025, through June 30, 2028, under the Cardiovascular Diseases Research program (CFDA 93.837). This research initiative will define the mechanisms by which impaired mitochondrial function leads to failure of neutrophil development in patients with severe congenital neutropenia (SCN) caused by CLPB...

The National Heart, Lung, and Blood Institute awarded a $158,976 Project Grant to The Children's Hospital of Philadelphia Research Institute, effective September 1, 2025 through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports research investigating the dysregulation of transcription factors and chromatin architecture in trisomy 21 (Down syndrome)-associated hematopoietic disorders, specifically examining transient abnormal myelopoiesis (TAM)...

Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $489,500 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective June 5, 2025, through May 31, 2027. The award funds research and development activities focused on translating the compound REPSOX and its analogs toward clinical application as a prophylactic intervention for Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM),...

This federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), CFDA #93.350, aims to develop a consensus-driven measurement strategy for assessing cognitive function in patients with thrombotic thrombocytopenic purpura (TTP), a rare and life-threatening blood disorder. The $456,348 award to Duke University, scheduled to be completed by July 31, 2026, will fund a study to determine the impacts of TTP on cognitive function and establish a rigorous...

Federal Grant Award Summary The National Institute of Child Health and Human Development awarded a $422,916 Project Grant to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany, effective August 1, 2025, through July 31, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This research project investigates the functional consequences of inosine triphosphate pyrophosphatase (ITPASE) deficiency and inosine...

Federal Project Grant Award Summary Baylor College of Medicine received a $1,371,664 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2025 through February 28, 2029. The award funds research to develop and validate a high-throughput microfluidic device utilizing Controlled Incremental Filtration (CIF) technology for purifying platelets intended for pediatric and neonatal transfusions. The...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $445,708 to Brigham & Women's Hospital Inc. to investigate the impact of ABO blood group antigens on platelet function and their role in hemostasis and thrombosis. The 3-year project aims to: 1) Define how ABO(H) glycans on platelet glycoproteins affect binding to von Willebrand factor, and 2) Identify the specific platelet glycoproteins that carry ABO(H)...

Federal Grant Award Summary Award Details: Vitalant Research Institute received a $375,306 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through May 31, 2029. Products and Services: This research project advances personalized transfusion medicine by investigating optimal platelet storage and supplementation procedures to improve hemostatic function in actively bleeding...