Project Grant R44GM161324
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- This Project Grant award of $1,249,099 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports the development of a new class of small, bright, tunable, and biocompatible near-infrared (NIR-II) fluorescent probes for deep tissue molecular imaging. The University of California, Irvine (UC Irvine) will create a palette of DNA-stabilized silver nanoclusters (AgN-DNA) that emit in the NIR-II tissue transparency window (1,000-1,700 nm). These new...
- This $306,872 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of a set of reagents that combine fluorescence tags with gold nanoparticle electron microscopy (EM) labels. These "correlative light and electron microscopy" (CLEM) reagents will enable highly multiplexed mapping and superresolution microscopy to better localize molecular...
- This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent...
- This $769,749 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences will support the development of Fluorescence Enhanced Photothermal Infrared Spectroscopy (FE-PTIR) technology by Photothermal Spectroscopy Corp. The FE-PTIR technique aims to provide simultaneous fluorescence microscopy and sub-micron infrared spectroscopy to map the distribution of fluorescently labeled biomolecules within cells and tissues while also analyzing their chemical...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- The National Institute of General Medical Sciences (NIGMS) awarded Trestle Optics LLC a $305,647 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop a novel photothermal microscopy system for non-destructive, high-resolution screening and sorting of microalgae to identify and enrich strains producing high-value polyunsaturated fatty acids. The project aims to engineer and prototype a microfluidic platform integrating photothermal imaging...
- This National Science Foundation (NSF) Project Grant award under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $305,000 in funding to Nanores LLC for the development of a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues at nanoscale resolution and depths up to 250 micrometers. The project aims to advance fluorescence imaging capabilities to enable breakthroughs in drug discovery, disease...
This federal Project Grant award, totaling $850,740 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The key objectives are to: Develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands to enable 56-plex imaging for deep immune profiling of cells in tissue samples. Demonstrate even higher 168-plex imaging using cyclic imaging with only 3 cycles, enabling extremely deep cell immuno-phenotyping for clinical discovery and research applications. The narrow-absorption PDots developed under this award will be immediately applicable for use with existing commercial instruments and will enable a new spectral imaging technology inspired by spectral flow cytometry. This project addresses the need for detecting tens to hundreds of protein markers in tissue samples in a simple, timely, and affordable manner, with significant implications for spatial biology, pathology workflows, and molecular diagnostics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $850.7k | 7/25/25 |