Project Grant R44GM161195
- The National Institute of General Medical Sciences awarded Monod Bio, Inc. $330,955 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational protein design methods for robust and scalable recombinant horseradish peroxidase (HRP) and poly-HRP reagents. Current HRP reagents derive from horseradish root, yielding heterogeneous mixtures of isoenzymes with variable glycosylation patterns, activity, and stability that compromise...
- The National Institute of General Medical Sciences awarded Potomac Affinity Proteins, LLC $377,602 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing R43GM159468) to develop protease chain reaction (PROCR) technology for rapid, highly sensitive, and quantitative detection of biomolecules in mix-and-read assays. The recipient will engineer protease and inhibitor components to optimize catalytic turnover and detect three target...
- The National Institute of General Medical Sciences awarded Michigan Technological University $383,801 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop cost-effective, scalable biosensing platforms for rapid multiplex biomarker detection in sepsis, allergy, and other complex diseases. The research focuses on molecularly imprinted polymers (MIPs)—synthetic receptors that mimic antibody recognition with superior stability and lower production...
- This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of Delaware $1,000,000 on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to develop a protein-based biosensor system for real-time monitoring and metabolic control of acetyl-CoA in microorganisms. The project, TOOLS4CELLS, will create a biosensor that enables rapid, sensitive detection of acetyl-CoA levels during microbial fermentation, addressing a critical gap in...
- This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
- The National Institute of General Medical Sciences awarded President and Fellows of Harvard College $125,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical biosensors that accelerate pharmaceutical biocatalyst engineering. The project, titled "Deploying Biosensors to Accelerate Pharmaceutical Biocatalyst Development," addresses manufacturing bottlenecks in drug production by engineering bacterial transcription factors...
- The National Institute of General Medical Sciences awarded Battelle Memorial Institute's Pacific Northwest National Laboratory $492,167 on August 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a high-throughput multiomic platform for simultaneous single-cell profiling of proteins, transcripts, and metabolites. The platform integrates novel chemistry, advanced mass spectrometry, and automated nanodroplet processing to analyze thousands of individual...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of California Santa Cruz $234,750 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop a de novo binder-luciferase platform for multiplexed protein detection in Western blots and lateral flow assays. The project will replace antibody-based detection reagents with computationally designed, thermostable de novo...
- Federal Project Grant Award Summary Molariti Inc. received a $316,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel solid-state nanopore array chip technology for biomolecule analysis. The award, effective September 1, 2025, through August 31, 2027, supports research aimed at creating scalable nanopore fabrication methods that overcome current limitations in existing...
The National Institute of General Medical Sciences awarded Monod Bio, Inc. $377,260 for design and development of rapid, quantitative biosensors using computational protein design, with an award date of August 1, 2026. Monod Bio is advancing its NovoLISA technology to transform biosensing methods in life sciences research. The work addresses limitations of traditional biosensing approaches such as ELISAs, which require 90–270 minutes for results, involve complex procedures, demand extensive antibody development time, and carry risk of cross-reactivity due to insufficient antibody validation. The NovoLISA assay offers a rapid alternative. This is a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859), which supports basic research to increase understanding of biological processes and lay foundation for advances in disease diagnosis, treatment, and prevention. Performance takes place in Seattle, Washington, with a period of performance ending May 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $377.3k | 8/3/26 |