Project Grant R44GM161182
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $385,298 project grant to The Research Foundation for The State University of New York (Stony Brook University) for the period of February 1, 2025 to December 31, 2029. The project aims to develop a new biomimetic organic synthesis approach that leverages rationally designed pyridoxal-5'-phosphate (PLP)-mimicking catalysts to enable open-shell radical...
- The National Institute of General Medical Sciences (NIGMS) awarded Fluorofinder, LLC a $356,190 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to advance a novel microscopy workflow tool. The tool is designed to streamline assay development, improve awareness and education around optimal selection of microscopy assay components (instruments and reagents), and enhance reproducibility in the field. The project aims to address common challenges in...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded Owic Technologies Inc. a $290,670 Project Grant to develop an innovative "Smart Photoelectronics for Electrochemical Synthesis (SPECS)" platform. This platform aims to enable high-throughput electrosynthesis to accelerate the discovery of novel small-molecule drugs for pharmaceutical applications. The project, which runs from Aug 1, 2025 to Jul 31, 2026, will create a user-friendly microelectronic chip technology that integrates into commercial 96- and 384-well plates. These SPECS devices will use photodiodes to wirelessly power on-chip electrodes and drive electrochemical reactions, eliminating the need for traditional wired equipment. This is expected to substantially enhance researchers' ability to access novel compounds and accelerate drug discovery efforts compared to traditional synthetic methods.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $290.7k | 7/28/25 |