The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
This Project Grant award of $408,007 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a technology called "glycosequencing" that uses next-generation sequencing (NGS) to sequence and quantify glycan structures. The project will first identify an optimal set of lectins, biochemically characterize them, and prepare lectin barcoding for NGS. It will also build a training dataset using recombinant proteins produced in glycoengineered Chinese...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will provide $390,000 to Georgia State University Research Foundation Inc. over a 5-year period starting February 1, 2025. The funding will support the development of a small molecule-based platform to map the reader proteins of glycosylation, which play critical roles in cell-cell communication, tumor metastasis, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is focused on developing enabling biotechnology tools to advance fundamental studies of glycosylation. The $363,177 award, spanning July 2025 to June 2030, supports research at West Virginia University Research Corporation (WVURC) to create miniaturized native enzymatic reactions integrated with separation-based assays using...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...
The National Institutes of Health National Institute of General Medical Sciences awarded a $903,000 Project Grant to The University of Toledo to develop new glycosylation methods for microbial glycan synthesis under the Biomedical Research and Research Training program (CFDA 93.859). Over a three-year period from September 2022 to August 2025, the University will create two new catalytic glycosylation methodologies - a cationic gold(I)-catalyzed glycosylation using glycosyl...
The National Institute of General Medical Sciences (NIGMS) awarded a $645,712 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Trustees of Tufts College in Medford, MA. The grant supports the development of new chemical biology tools to study protein post-translational modifications, specifically glycation and ubiquitination, in living cells. The research aims to uncover how these modifications are integrated into cellular signaling networks and...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel signal amplification technologies by Molecular Instruments, Inc. to enable automated, ultrasensitive, and multiplex imaging of RNA and protein expression in biological samples. The $1,099,625 award supports the engineering of two key capabilities: 1) a chromogenic signal amplification...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...