This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $308,925 to Chemia Biosciences, Inc. to develop computational technologies for discovering novel fungal natural products with potential antimicrobial and therapeutic applications. The primary goal is to create software that can predict the molecular structures of natural products encoded in fungal genomes, leveraging high-throughput...
This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $317,029 in funding to Chemia Biosciences, Inc., a small disadvantaged business, to develop advanced computational methods and software tools for discovering novel antimicrobial natural products. The project aims to leverage high-throughput mass spectrometry and genome mining techniques to identify new polysaccharides and aminoglycosides, a class of antibiotics, to address the growing...
This Project Grant award, identified as R35GM152006, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The award, valued at $752,456, supports the University of Pittsburgh in developing innovative, user-friendly computational technologies to (1) identify new bioactive small molecules and (2) improve their pharmacological properties. This work aims to accelerate the drug discovery...
This Project Grant award of $350,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop an artificial intelligence-based platform for optimizing peptide-based drug candidates. The key products or services to be delivered include: Methods for encoding non-canonical amino acids and cyclic peptides to enable high-performance machine learning on commercial peptide sequence, activity, stability, and...
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Pittsburgh over a 5-year period from September 2024 to August 2029. The research aims to develop advanced computational and machine learning models that integrate diverse biomedical data, from genetics to transcriptomics and proteomics, to better predict the effects of therapies on diseased cells....
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is supporting research to identify and characterize novel dehydrated nonribosomal peptides from Streptomyces bacteria. The $300,892 award to the University of North Carolina at Chapel Hill aims to discover previously unknown dehydrated nonribosomal peptides, determine their biosynthetic pathways, and assess their potential...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program provides $350,000 to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. The proposed technology aims to enable scalable, multiplexed protein sequencing with high accuracy and throughput, surpassing the...