Project Grant R44GM156476
Award Date
9/20/24
Completion Date
3/19/25
Dollars Obligated
$206K
Federal Agency
National Institute of General Medical Sciences
Awardee
Abbratech Inc. (G7S7M6L41EX5)
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Branford, CT 06405, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $917,454 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to Integral Molecular Inc. The purpose of this 3-year grant, starting on Sep 1, 2024, is to develop a novel Membrane Proteome Array (MPA) technology for specificity profiling and deorphaning of monoclonal antibodies and other biotherapeutics. The MPA represents 93% of the human extracellular proteome expressed in native...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to enhance antibody discovery workflows by developing innovative screening and selection technologies utilizing Partillion Bioscience's specialized hydrogel microparticle (nanovial) platform. The $1,000,000 award will support the company's efforts to significantly increase throughput (10X) for functional antibody...
This SBIR Phase I award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $273,550 to Biocognon LLC for the development of a combinatorial platform to discover improved molecular recognition components for use in therapeutic and diagnostic antibodies. The project aims to utilize synthetic biology, next-generation DNA sequencing, and computational biology to efficiently generate and screen libraries of antibody...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California. The purpose of this grant is to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. This innovative platform will leverage enzymatic processing and advanced bioinformatics to accurately sequence peptides with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial nanobody discovery platform targeting G-protein coupled receptors (GPCRs). The project aims to establish a robust system for assembling GPCR/nanobody libraries, build a synthetic nanobody library targeting the ADRB1 and ADRB2 GPCRs, and implement a...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $415,329 to Northern Illinois University (NIU) to explore methods for controlling antibody-antigen interactions through the introduction of acidic residues at the interface. The research aims to develop antibody variants with pH-dependent switches, allowing the protein interactions to be modulated. This work has the potential to open...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is supporting the development and evaluation of a system for fast analysis of antibodies and related macromolecular immune complexes. The project aims to realize high-mass ion detection using a novel high-temperature superconducting nanowire detector in a time-of-flight (TOF) mass spectrometer with matrix-assisted laser...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to advance the understanding of mRNA splicing mechanisms and their impact on biological function. The $1,612,448 award, effective from July 19, 2024 to May 31, 2029, will support the development of computational methods to study RNA splicing in human biology and disease, characterize splicing-mediated regulation...
This National Science Foundation Project Grant of $255,927 awarded to Invvax, Inc. on March 1, 2022 seeks to develop stable prophylactic antibodies through February 2023. Funded through the NSF Engineering Directorate's CFDA 47.041 program, this Small Business Innovation Research Phase I project will engineer mutations to antibody Fc regions to resist degradation and enhance binding to the neonatal Fc receptor for potentially decades-long duration. Specifically, the awardee will combine known...
The National Institute of General Medical Sciences (NIGMS) awarded a $363,392 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University to develop computational methods to characterize alternative splicing and genetic determinants from heterogeneous sequence data. The project aims to create a general framework and specialized tools to detect and analyze splicing variation from diverse RNA sequencing data, model alternative splicing and its regulatory...