Project Grant R44GM154510
Award Date 9/1/25
Completion Date 8/31/27
Dollars Obligated $1.3M
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Research Triangle Park, Durham, NC, USA
Similar Awards
- The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The grant supports the development of "Epigenetic Editor Therapeutics" - a novel approach to modulating gene expression without altering the DNA sequence. The project aims to create recombinant, self-delivering epigenetic editor proteins that can be taken up by cells and targeted to...
- This Project Grant award of $306,094 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a novel epigenetic editing platform by Active Motif, Inc., a biotechnology company based in Carlsbad, California. The platform uses a new targeting approach to recruit epigenetic effectors to specific genomic loci, enabling targeted alterations to the epigenetic landscape without permanently changing DNA sequences. This innovative technology has...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), funded under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and commercialization of the AlidaBio EpiPlex V2 assay. This platform aims to provide researchers with a comprehensive method for simultaneously detecting and quantifying the three most prevalent RNA modifications: N6-methyladenosine (m6A), inosine (I), and pseudouridine (Ps). The $1,146,785 award,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc. to develop the first technology capable of high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A) using nanopore sequencing. The project aims to merge innovative bisulfite adduct methodology with Electronic Biosciences' enzyme-free, multipass...
- This federal Project Grant award, valued at $442,750.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the regulation of canonical and non-canonical substrates of histone lysine methyltransferases. The research aims to address key knowledge gaps in understanding the mechanisms of active chromatin inheritance and systematically investigating the importance of...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This Project Grant award of $1,792,800.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a nuclear alpha-ketoglutarate (AKG) biosensor system to study the metabolic control of the epigenome. The project, awarded to the University of Texas Southwestern Medical Center, will create a new biomedical research tool to quantify changes in nuclear AKG levels with high...
- The National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, awarded a $148,880 Project Grant to Duke University to develop an ultra-high-throughput platform called Phage- and Robotics-Assisted Near Continuous Selection (PRANCS). The goal is to systematically characterize the natural specificity and impact of mutations on reader domain interactions with acetyl-modified histone subunits. The project aims to build improved...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...