Project Grant R44GM154507

Award Date 7/1/24
Completion Date 6/30/26
Dollars Obligated $948K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Troy, NY, USA
Similar Awards
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of a multi-functional Plasmonic Scattering Microscopy (PSM) instrument. The PSM technology enables high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native microenvironment. This addresses an unmet...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $349,816 to Narwhal Bio, Inc. to develop a prototype instrument, software, and consumable for non-invasive, live-cell identification, tagging, and downstream characterization. The goal is to enable researchers to study clinically relevant cell-cell interactions, which drive many challenging diseases like cancer, autoimmunity, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $366,250 to Central Michigan University to develop bioluminescent kinase sensors for monitoring cell signaling processes related to cell growth, division, and the cell cycle. The goal is to create real-time, non-invasive tools to enhance the understanding of cell biology and disease progression, with potential for...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to expand the understanding of adherent cell mechanics and mechanobiology. The research program leverages cell biophysics, molecular cell biology, live cell imaging, mathematical modeling, and optogenetics to investigate the force-sensitive remodeling of cell-cell adhesions and the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to understand how metabolic conditions influence the behavior of human cells. The $421,600 award to the Morgridge Institute for Research, Inc. will be used to pursue three main objectives over the 5-year project period from 2025-2029: 1) elucidating context-dependent genetic contributions to cell growth, 2) examining...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,965,880 to Ascent Bio-Nano Technologies, Inc. to develop an acoustic-based "Smart Petri Dish" for contact-free, precise manipulation of delicate bioparticles such as cells and extracellular vesicles. The project aims to create a fully integrated, multifunctional acoustic tweezers system on a Petri dish that can...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $665,616 to develop a novel micro-capsule technology that enables high-throughput analysis of millions to hundreds of millions of live cell-cell interactions in parallel. The project aims to establish and benchmark two prototype methods: (1) high-throughput screening of cell-cell interactions, and (2)...
This federal Project Grant award of $333,048.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of a 2-photon microscopy version of the "Spotlight" optical cell isolation technology by Imagen Bioworks Inc. The goal is to create a versatile platform that can isolate individual cells from three-dimensional samples after spatial and temporal profiling. This will enable research in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $438,629 to the University of Massachusetts to conduct research on the fundamental mechano-molecular mechanisms of cell division. The primary objectives are to investigate the role of intrinsically disordered protein regions in regulating cell division processes, and to study the regulation of branching microtubule...
This National Science Foundation (NSF) Project Grant under the Engineering program (CFDA 47.041) will develop automated lab-on-a-chip platforms to enable comprehensive monitoring and control of live cell physiology. The $406,165 award to George Washington University, starting on September 1, 2024, will fund research to create innovative materials, devices, circuits, software, and integrated systems for real-time, multiparametric analysis of live cell models like induced pluripotent stem...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provided $947,705 to Applied Biophysics, Inc. to develop an innovative "Cell Assurance Monitor" (CAM) instrument. The CAM is designed to assist researchers in detecting issues such as cell line misidentification, mycoplasma contamination, and changes in cell populations during long-term cell culture. By monitoring the complex impedance of cells grown on electrodes, the CAM aims to provide a quantitative and affordable means to complement traditional microscopy-based cell analysis methods. The project, awarded from July 2024 to June 2026, will leverage multivariate statistical analysis techniques to identify the most discriminating impedance-based features for characterizing different cell lines and detecting contamination problems that can undermine biomedical research efforts.

Generated 4/8/25, 3:53 AM