This Project Grant award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $305,000 to Atomnaut Inc. to investigate the feasibility of a new microscope sample vessel technology to enable routine in situ vitrification and atomic-scale imaging of biomolecule structure and chemistry in 3D. The key objectives are to: (1) achieve a 1-day time-to-data by employing front filling, graphene sealing, and functionalizing a superhydrophilic lumen; and...
This $305,000 National Science Foundation (NSF) SBIR Phase I project grant, awarded on March 1, 2025, aims to develop a compact, multi-color super-resolution imaging system capable of visualizing molecular structures in thick biological tissues with nanoscale precision. The project addresses limitations of existing imaging technologies by incorporating advanced features such as adaptive optics and spinning disk technology to minimize optical aberrations and scattering. The research objectives...
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $942,983 to acquire a Bruker Luxendo TruLive3D light-sheet microscope system. The award, effective September 1, 2024 through August 31, 2025, will enable rapid 3D volumetric imaging of live specimens such as mouse, fly, and zebrafish embryos with high resolution and minimal phototoxicity. This advanced microscope system will benefit a user group of...
This three-year, $1,368,422 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports the development of cryogenic electron microscopy (cryo-EM) to study phase separation in lipid membranes. Frederick A. Heberle of the University of Tennessee and M. Neal Waxham of the University of Texas Health Science Center at Houston will optimize cryo-EM imaging techniques to visualize nanoscale lipid raft domains in cell membranes. Goals include...
This Project Grant award of $400,000 from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a new high-speed 3D dynamic contrast microscopic optical coherence tomography (3D DYC-μOCT) imaging system. The goal is to enable label-free, 3D visualization of ciliary beating dynamics in human airway organoids, which is essential for studying lung diseases and developing improved treatments. The key objectives are to: (1) engineer a broadband, high-coherence...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is providing $1,337,953.41 to the University of Arizona to develop and disseminate an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument for high-speed, sub-micron resolution volumetric imaging in deep tissue. The proposed instrument will enable faster...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $306,852 to Mitegen, LLC, a manufacturer of advanced scientific instruments and technologies located in Lansing, New York. The funding will support the development and validation of innovative cryopreservation technology that automates the soaking, cooling, and warming processes for small biological samples such as oocytes and...
The Department of Energy Office of Science awarded $250,000 to Star Cryoelectronics, LLC through its Office of Science Financial Assistance Program (CFDA 81.049) to develop a high-performance superconducting tunnel junction (STJ) soft x-ray detector for biological science. The STJ soft x-ray detector will utilize superconducting tunnel junction technology to detect soft x-rays at the nanoscale level for biological imaging and spectroscopy applications. The project aims to advance SC's mission to...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $1,999,997 to Arizona State University (ASU) to acquire an electron energy filtering system and direct electron detector camera to upgrade the university's cryo-electron microscopy (cryo-EM) capabilities. The new instrumentation aims to improve the resolution and data quality of cryo-EM studies, enabling ASU researchers to better investigate biomolecular...