Project Grant R44GM146477
- The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $507,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Icahn School of Medicine at Mount Sinai (ISMMS) to develop an automated system that integrates micro-electromechanical sensors, automation, and machine vision to simultaneously measure the electrophysiological properties and contractile forces of single human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). This...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $305,000 to Cellecho, Inc. to develop a microchip-based technology for advanced cell engineering. The goal is to create a miniaturized liquid and cell handling platform that leverages acoustic-electric micro-vortices to precisely and sequentially deliver genetic molecules. This innovation aims to make complex cell reprogramming more...
- This $256,000 National Science Foundation Project Grant under the NSF Technology, Innovation, and Partnerships program will support the development of a universal connector for high-density microfluidic chip interfaces by Neptune Fluid Flow Systems LLC. The proposed connector aims to advance lab-on-a-chip and other life science platforms by introducing a standardized microfluidic chip interface. This new interface seeks to dramatically increase diagnostic testing speeds for doctors and medical...
- Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...
- This Project Grant award of $432,834 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with a performance period from April 15, 2025 to March 31, 2028. The objective is to develop an enzyme-free, label-free quantitative microarray technology to accurately measure and quantify small nucleic acid targets such as microRNA in the attomolar range for applications like liquid biopsy. The research...
- This $295,308 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development and validation of a novel class of scanning probe microscopy (SPM) probes for rapid identification of infectious disease agents. The awardee, Actoprobe LLC, aims to dramatically improve the sensitivity and spatial resolution of scanning...
- This Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Dcan Biosciences LLC to develop an advanced microfluidic system for cancer diagnosis and monitoring. The system aims to isolate and assess circulating tumor cells (CTCs) and CTC clusters (CTCCs) from patient blood samples to enable highly sensitive and accurate liquid biopsies. Key objectives include designing a hybrid microfluidic device for...
- This $600,120 federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports the development of a groundbreaking microfluidic-based weighing instrument capable of measuring mass changes in live single cells with picogram accuracy and millisecond resolution. The Icahn School of Medicine at Mount Sinai, a prominent academic medical research institution, will lead this 4-year research project. The instrument will utilize small pipettes to...
A MICROMACHINING FLUIDIC CANTILEVER FOR SINGLE CELL ADVANCED PATCH CLAMPING AND CELLULAR CHARACTERIZATION USING ATOMIC FORCE MICROSCOPY - SINGLE PATCH CLAMPING IS USED TO MULTIPLE AREAS OF BIOLOGY SUCH AS CARDIOLOGY (CARDIOMYOCYTES), NEUROLOGY/NEUROSCIENCE (NEURONS), ENDOCRINOLOGY (PANCREATIC BETA CELLS), MYOLOGY (MUSCLE FIBERS), AND EVEN MICROBIOLOGY (BACTERIAL ION CHANNELS). APPLIED NANOSTRUCTURES (APPNANO) IN PARTNERSHIP WITH THE ICAHN SCHOOL OF MEDICINE IS BRINGING TO THE MARKET A UNIQUE SOLUTION ADDRESSING A MAJOR MARKET NEED IN ELECTROPHYSIOLOGY MEASUREMENTS. WITH ITS ADVANCED FEATURES AND UNMATCHED RESOLUTION, THE DEVICE WILL ENABLE RESEARCHERS IN ACADEMIA AND IN THE HIGHLY COMPETITIVE LIFE SCIENCES INDUSTRY TO ANSWER IMPORTANT SCIENTIFIC QUESTIONS AND DEVELOP AND TEST NEW DRUGS FUELING THE DISCOVERY OF NEW PHARMACEUTICAL SOLUTIONS. AS A RESULT, THESE COMPANIES WILL BE BETTER EQUIPPED TO KEEP UP WITH THE EVER-INCREASING CONSUMER DEMAND FOR PHARMACEUTICAL PRODUCTS. IN THIS SBIR WE ARE DEVELOPING A SEMI-AUTOMATED SYSTEM BASED ON AN MICRO-ELECTROMECHANICAL SYSTEMS (MEMS) SENSOR PIPETTE USED WITH ATOMIC FORCE MICROSCOPES (AFM) THAT CAN MEASURE, SIMULTANEOUSLY AND DIRECTLY, ELECTROPHYSIOLOGICAL PROPERTIES (SUCH AS ACTION POTENTIALS (AP)), CONTRACTILE FORCES ON SINGLE CARDIOMYOCYTES (CM), AND SINGLE CELL ELASTICITY. THIS SYSTEM OFFERS HIGH CONTENT ANALYSIS (HCA) AT A SINGLE CELL LEVEL. THE SYSTEM ENABLES A SIGNIFICANT INCREASE IN PERFORMANCE AND A DRAMATIC DECREASE IN TIME TO COMPLETE A MEASUREMENT. WITH TIMES
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/5/25 | ||
| Not listed | $805.2k | 4/12/23 | ||
| Not listed | $680.4k | 4/29/22 | ||
| Not listed | $680.4k | 4/29/22 |