Multi-omics profiling of individual exosomes for origin-tracing, biomarker discovery, and biological function characterization

Ended Project Grant Awarded Last action

Award ID
R44GM145015
Recipient
Awarding agency
Obligated
$1,662,647

Award facts

Assistance listing
93.859 Biomedical Research and Research Training
Completion date
Place of performance
San Jose, CA 95134, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Extracellular vesicles (EVS) exhibit high heterogeneity in biofluids, a feature that traditional bulk-level analysis approaches fail to capture in terms of individual variations. While numerous techniques exist for single-EV analysis, the majority focus primarily on profiling surface proteins. Transcriptional analysis at the level of individual EVS, however, remains largely unexplored. To bridge this GAP, we propose the development of a technology for multimodal profiling of individual EVS, leveraging next-generation sequencing and an optimized method for multiplex library preparation. This proposed platform will serve as a unique tool for high-throughput, integrative profiling of single-EV gene expression and surface proteins. IT aims to offer high-sensitivity, multi- dimensional biological insights, thereby potentially accelerating the advancement of EV-based diagnostics and targeted therapies.

Transactions

Action Obligated Date
Amendment $122,815
Amendment $738,347
Original award $801,485

Quick answers

Who received award R44GM145015?

R44GM145015 was awarded to Wellsim Biomedical Technologies Inc. by National Institute of General Medical Sciences (National Institutes of Health) on July 25, 2024.

How much is award R44GM145015 worth?

$1,662,647 has been obligated on R44GM145015.

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