A label-free extracellular-vesicle automated purification system (leap system)
Ended Project Grant Awarded Last action
- Award ID
- R44GM144009
- Recipient
-
Wellsim Biomedical Technologies Inc. UEI FD9MPD9K3EC1
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,498,809
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date
- Originally
- Place of performance
- California, USA
Award details come from USAspending.gov.
Description
- Abstract
- Extracellular vesicles (EVS) are small lipid bilayer particles secreted by most cell types, which encapsulates biomolecules including lipids, proteins, and nucleic acids from cells of origin. Profiling of EV-derived biomarkers provides a promising approach for diagnosis of various diseases. However, one of the primary challenges for the research and application of EVS is a lack of a reliable method for efficient isolation of EVS and their subpopulations from complex biofluids. Researchers in this field suffer from tedious workflow, long processing time, high cost, and poor EV quality. To overcome the challenges, wellsim proposes in this phase II project, which built upon the promising results generated from our phase I project, to complete development of a label- free extracellular-vesicle automated purification system (leap system) for isolation of total EVS or EV subpopulations from a variety of biofluids in a non-invasive and cost-effective manner. Once developed, the integrated leap system will offer excellent EV quality, throughput, and flexibility for EV isolation that can outperform ultracentrifugation and other isolation techniques.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $749,163 | |
| Original award | $749,646 |
Quick answers
Who received award R44GM144009?
R44GM144009 was awarded to Wellsim Biomedical Technologies Inc. by National Institute of General Medical Sciences (National Institutes of Health) on June 16, 2022.
How much is award R44GM144009 worth?
$1,498,809 has been obligated on R44GM144009.
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