Project Grant R44GM131430
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
- This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $313,963 to Z Biotech, LLC to develop a comprehensive library and array of tumor-associated carbohydrate antigens (TACA). The goal is to create tools to systematically evaluate TACA interactions with therapeutic antibodies, biologics, and glycan-binding proteins, in order to advance the development of TACA-targeted...
- This $315,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of chemoenzymatic methods and reagents to produce affordable glycosphingolipids (GSLs), a class of lipids with complex carbohydrate structures that are ubiquitous in cell membranes. The key objectives are to: 1) expand the inventory of commercially available recombinant glycosyltransferase enzymes...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $313,827 Project Grant to Lectenz Bio, Inc. in Georgia. The grant supports the development of "innovative glycan-specific reagents to accelerate the detection of disease biomarkers". Specifically, the project aims to engineer a high-affinity reagent derived from a glycan-processing enzyme to detect high-mannose glycans, which are known...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $454,478 to The Johns Hopkins University for a project titled "Perfecting Tools to Define the Glycan-Protein Interactome". The project aims to develop advanced chemical probes and computational techniques to map the interactions between glycans (sugar structures) and proteins, which play critical roles in regulating cell physiology and...
- This $327,085 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of new tools and strategies to advance the understanding of lectin proteins and their roles in human health. The key objectives of this 1-year project include: 1) Creating tools to assess how soluble human lectins interact with and influence microbial communities, 2) Developing a...
- The National Institute of General Medical Sciences (NIGMS) awarded a $202,467 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Acpharis, a biotechnology software company based in Holliston, Massachusetts. The grant supports the development of a commercial-quality software product that integrates machine learning with physics-based computational approaches to accurately predict the structures of antibody-antigen complexes. This breakthrough technology,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial pipeline for discovering nanobody-based therapeutics targeting G-protein coupled receptors (GPCRs). The key products and services to be delivered under this award include: (1) developing a robust assembly system for GPCR and nanobody libraries, (2) building a...
BIOINFORMATIC TOOLS FOR INTERPRETATION OF GLYCAN ARRAY DATA - PROJECT SUMMARY / ABSTRACT THERE IS AN URGENT NEED OF ANALYSIS TOOLS FOR MINING GLYCAN ARRAY DATA IN ORDER TO ACCURATELY AND STATISTICALLY STUDY THE INTERACTIONS BETWEEN CELL-SURFACE GLYCANS AND GLYCAN-BINDING PROTEINS. IN THIS SBIR PROGRAM WE PROPOSE TO DEVELOP A SOFTWARE AND HARDWARE INTEGRATED SYSTEM FOR ANALYSIS AND INTERPRETATION OF GLYCAN ARRAY DATA. THE PROBLEM WITH EXISTING GLYCAN ARRAY DATA MINING TOOLS IS THAT THEY GIVE BINDING INFORMATION ONLY FOR SIMPLISTIC SUBSTRUCTURES OF GLYCANS AND NOT COMPLEX BINDING DETERMINANTS, AND THEY LACK CONSISTENT SIGNAL QUANTIFICATION IN AN AUTOMATED WAY. TO SOLVE THIS PROBLEM, Z BIOTECH, LLC (A GLYCAN ARRAY PROVIDER) IS TEAMING WITH DR. BRIAN HAAB'S LAB AT THE VAN ANDEL INSTITUTE (A SOFTWARE PROVIDER) TO DEVELOP AND IMPROVE A ROBUST GLYCAN-ARRAY DATA MINING TOOL (MOTIFFINDER) AND A GLYCAN-ARRAY IMAGE ANALYSIS PROGRAM (SIGNALFINDER). Z BIOTECH HAS INVENTED A ROBUST GLYCAN ARRAY PLATFORM HAVING THE ADVANTAGE TO DISPLAY GLYCANS ON SOLID SURFACES IN A MULTIVALENT FORM. THE GLYCAN ARRAYS Z BIOTECH PROVIDES HAVE SUPERIOR PERFORMANCE WITH THE CRITERIA FOR A HIGH-QUALITY MICROARRAY, WHICH IS SUITABLE FOR GENERATION OF GLYCAN ARRAY DATA FOR EVALUATION OF ANALYSIS TOOLS LIKE MOTIFFINDER AND SIGNALFINDER. IN ADDITION, THE HAAB RESEARCH GROUP HAS BEEN LEADING DEVELOPMENTS IN GLYCAN-ARRAY ANALYSIS TOOLS. THEY WERE THE FIRST TO PUBLISH AN ALGORITHM FOR THE ANALYSIS OF GLYCAN-ARRAY DATA IN 2010, AND SUBSEQUENTLY HAVE CONTRIBUTED MANY INNOVATIONS. IN THE PHASE I PROJECT, WE DEVELOPED MOTIFFINDER FOR FULLY AUTOMATING THE ANALYSIS, INCLUDING NEW APPROACHES FOR IDENTIFYING SUBTLE PATTERNS AND FEATURES IN THE GLYCAN ARRAY DATA. IN ADDITION, WE DEVELOPED SIGNALFINDER FOR THE AUTOMATED IMAGE ANALYSIS OF GLYCAN-ARRAY IMAGES. THIS SOFTWARE PROGRAM ADDRESSES THE PREVIOUS BOTTLENECKS AND LIMITATIONS IN THE ARRAY IMAGE ANALYSIS. IT IS BUILT ON THE UNIQUE ALGORITHM THAT HAS FUNCTIONED WELL FOR THE AUTOMATED ANALYSIS OF IMMUNOFLUORESCENCE AND MICROARRAY IMAGES. THE GOAL FOR THE PHASE II PROJECT IS TO ENHANCE THE ABILITY OF THE TWO GLYCAN-ARRAY MINING TOOLS THROUGH TESTING ON GLYCAN ARRAYS WITH THE EXPANDED GLYCAN LIBRARY. THE RESULTANT GLYCAN-ARRAY ANALYSIS SYSTEM WITH HARDWARE AND SOFTWARE WILL HAVE A BROAD IMPACT ON GLYCOBIOLOGY RESEARCH, GLYCAN-RELATED BIOMARKER CHARACTERIZATION, AND NEW DRUG DEVELOPMENT TARGETING GLYCANS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 4/11/25 | ||
| Not listed | $544.9k | 1/23/23 | ||
| Not listed | $544.9k | 1/23/23 | ||
| Not listed | $544.9k | 2/2/22 | ||
| Not listed | $544.9k | 2/2/22 |