Project Grant R44GM125438

The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $380,375 Project Grant to Ceretype Neuromedicine Inc. to design and develop an advanced functional MRI (fMRI) software platform as a medical device for use in clinical trials and therapeutic applications in neuropsychiatry. The key objectives of this Fast-Track SBIR project are to: 1) Engineer an fMRI system for industry-backed trials that meets regulatory requirements...

This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $830,409 to Brigham & Women's Hospital Inc. to develop novel software and computational techniques integrating real-time transcranial magnetic stimulation (TMS) electric-field mapping, electroencephalogram (EEG) source imaging, and subject-specific target localization. The goal is to enhance the accuracy of TMS targeting and dosimetry to...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of a silent, whole-brain functional magnetic resonance imaging (fMRI) acquisition method called Looping Star. The $432,749 project, which runs from March 1, 2025 to January 31, 2029, aims to design and optimize the Looping Star fMRI acquisition to...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $390,616 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the Regents of the University of Michigan for the development of layer-specific functional magnetic resonance imaging (fMRI) techniques for clinical 3 Tesla scanners. The goal is to improve signal-to-noise ratio and reduce scan time for layer-specific fMRI, which currently...

This $4.28 million project grant from the National Institutes of Health's National Institute on Aging will fund research at Massachusetts General Hospital from August 2022 to May 2025 to investigate the neurophysiological basis of circuit-specific laminar resting-state functional magnetic resonance imaging (RS-fMRI). The grant aims to elucidate the relationship between laminar-specific bilateral low-frequency fluctuations seen on RS-fMRI and transcallosal projections between brain hemispheres....

This $276,000 National Science Foundation award through the Technology, Innovation, and Partnerships program will support the development of a cognitive dashboard software platform to aid neurosurgical clinical decision-making. Mindtrace Technologies, Inc. will deliver a turn-key software solution that enables neurosurgical teams to map individual patient brain functions, assess and track measures of mental performance throughout care, and integrate with existing medical imaging and data...

This $1,920,113 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), seeks to conduct a deep dive on the anatomy and function of the anterior lateral prefrontal cortex (ALPFC) region of the brain in neurotypical adults. The principal investigators will leverage cutting-edge 7 Tesla MRI technology to: Evaluate the domain-generality of ALPFC by assessing its activation and interactions with other brain regions...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund research to advance functional MRI (fMRI) methods for studying cerebral cortical layers in the human brain. The $156,656 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) will enable a series of experiments to benchmark and validate the use of "linescan fMRI", a high-resolution MRI technique,...

This $2,621,650 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports a multi-site clinical trial to test the diagnostic and prognostic utility of a transcranial magnetic stimulation-electroencephalography (TMS-EEG) device for critically ill patients with acute disorders of consciousness. The primary goal is to develop standardized TMS-EEG...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $666,530 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Weill Medical College of Cornell University. The objective of this 5-year project is to develop an MRI-based cerebral metabolic rate of oxygen consumption (CMRO2) mapping technique to evaluate ischemic lesion viability in acute stroke patients. The project aims to validate the MRI-based CMRO2...