Project Grant R44GM117849

This $274,547 Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a novel Aneurysm Sealing Device (ASD) for endovascular treatment of Abdominal Aortic Aneurysms (AAA). The project seeks to create a device that can completely seal the aneurysm sac, reducing the risk of post-procedure complications and the need for repeat interventions. Key objectives include validating the device's adaptability...

This National Science Foundation (NSF) Engineering Research Initiation (ERI) Project Grant, awarded by the NSF Division of Chemical, Bioengineering, Environmental, and Transport Systems, aims to develop a new type of bioadhesive using hydrophilic polydopamine (HPDA) to improve healing of inner meniscus tears. The project will synthesize and characterize HPDA, then incorporate it into hydrogel-based bioadhesives to be tested in vitro. The specific objectives are to understand the adhesion...

This $252,906 National Science Foundation project grant supports the development of scalable manufacturing methods for peptide amphiphile molecules by Amphix Bio Inc. The goal is to advance a safer and more affordable alternative to recombinant proteins currently used in spinal fusion surgeries. Over 500,000 such surgeries are performed annually in the U.S. to treat back and neck pain. While peptide amphiphiles show promise for reducing biological dose needs and offering consistent outcomes,...

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

This National Science Foundation Technology, Innovation, and Partnerships grant award of $250,000 provides funding from August 15, 2022 to July 31, 2024 to develop and evaluate an absorbable surgical adhesive patch to reinforce internal suture lines in the urinary tract. The University of California, Los Angeles will receive the award to create a flexible, bioabsorbable internal suture reinforcement device aimed at significantly reducing post-operative complications and readmissions for...

This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award supports fundamental research into the puncture mechanics of soft solids, such as hydrogels and biological tissues. The $546,068 award to Georgia Tech Research Corporation, a non-profit research organization and state institution of higher education, will fund a 3-year study to provide a quantitative understanding of the fracture and penetration properties of ultra-soft materials. The research aims to develop...

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

This Project Grant award from the Defense Health Agency, under the Military Medical Research and Development program (CFDA 12.420), provides $4,000,000.00 in funding to Medcura, Inc. in Riverdale, MD to expand the development and production of a biopolymer powder treatment for noncompressible torso hemorrhage. The research aims to improve health outcomes for military service members and the broader public by advancing this innovative medical technology. The award period extends from Aug 5,...

Federal Project Grant Award Summary Perfusion Solutions Inc. received a $320,838 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 5, 2025, with completion targeted for February 28, 2027. The award supports Phase I development of a fail-safe, high-output cavopulmonary assist pump designed for pediatric and congenital heart disease patients with single ventricle physiology...

The University of Pittsburgh has been awarded a $747,131 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant, awarded on July 10, 2024, supports the development of an Extracorporeal Perfusion System (EPS) for composite tissue regeneration. This research effort aims to advance innovative medical technologies to improve health outcomes for military service members and the broader public. The grant will fund a...