Project Grant R44GM117682

This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development of a novel platform for protein engineering and production using a hybrid in-vivo, in-vitro, and in-silico approach. The $2,808,001 project, executed by Caravel Bio, Inc., aims to overcome the high costs and scalability challenges of cell-free biosynthesis through the integration of four advanced technologies:...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This $2,996,108 Cooperative Agreement awarded by the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop more efficient cell-free biomanufacturing processes. The project is creating membraneless compartmentalization techniques using custom-designed enzymes and innovative materials. This approach enables the simultaneous execution of multiple redox reactions required to produce valuable chiral chemicals, overcoming the...

This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,248,994 to Opera Bioscience, Inc., a woman-owned small business in Evanston, Illinois, to further develop an innovative bacterial protein secretion platform technology. The project aims to create a commercially viable, cost-effective protein expression platform capable of producing multiple classes of proteins at an industrial scale, while meeting...

This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a bioprocessing system to isolate and purify therapeutic antibodies directly from cell culture. The $999,998 award to Athem LLC, a minority-owned small business, will enable scaling up a novel nanoparticle-based purification media and an automated prototype system. The goal is to simplify the manufacturing of biologics, reduce...

This Cooperative Agreement award from the National Science Foundation (CFDA 47.084 - Technology, Innovation, and Partnerships) provides $3,091,750 to the Georgia Tech Research Corporation to develop a modular, standardized platform for cell-free bioprocessing. The project aims to create eight reusable modules covering essential functions like energy generation and protein expression, enabling faster and more efficient product development for cell-free technologies. By demonstrating how modular...

This SBIR Phase I project from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $304,997 to develop a scalable whey protein-based microcarrier platform to enable commercial-scale cultivated meat production. The project aims to address the lack of food-grade, scalable cell culture substrates suitable for consumable products by creating an edible microcarrier that can increase production rates and simplify manufacturing processes...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...

The National Science Foundation awarded Opera Bioscience, Inc. $275,000 under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a low-cost bacterial production platform for manufacturing high purity recombinant proteins and growth factors. The award period runs from June 15, 2023 through May 31, 2024. Opera Bioscience will utilize this funding to demonstrate the ability of its innovative protein production platform to solve challenges in traditionally costly and...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...