Project Grant R44GM116285

This $165,123 project grant from the National Science Foundation's Mathematical and Physical Sciences program will support the development of new computational methods and software tools for predicting polymorphic crystal structures of organic molecules and elucidating phase transition mechanisms. Mark Tuckerman of New York University and Jerome Delhommelle of the University of North Dakota will create a topological theory for crystal structure generation based solely on molecular order...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to improve the quality of cryogenic electron microscopy (cryo-EM) specimens. The $349,999 award to Denovx, LLC will fund research to develop innovative surface modifications for cryo-EM specimen supports that enhance the adsorption and random orientation of biological analytes, such as proteins and protein complexes. The researchers will...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $463,746 to the University of Puerto Rico Medical Sciences Campus (UPR-MSC) to study an innovative continuous crystallizer concept. The objective is to develop robust, scalable, and miniaturized equipment for pharmaceutical manufacturing that can improve resilience to supply chain disruptions and better meet fluctuating market needs. The research seeks to advance continuous...

The National Science Foundation (NSF) Office of Integrative Activities awarded a $124,802 Project Grant to the University of Oklahoma (OU) to study the growth of lead halide perovskite nanocrystals at the single-particle level. This research aims to advance the development of low-cost single photon emitters (SPEs) necessary for building future quantum photonic networks that enable secure quantum communications. Under this 2-year grant, starting September 1, 2023, Professor Yitong Dong and his...

The National Institute of General Medical Sciences (NIGMS) awarded a $905,853 Project Grant (CFDA 93.859) to Molecular Instruments, Inc., a for-profit manufacturer of scientific instrumentation located in Los Angeles, California. The grant, titled "Hybridization Chain Reaction: Automated Ultrasensitive Multiplex RNA and Protein Imaging," supports the development of innovative signal amplification technologies to enable automated, ultrasensitive, and multiplex imaging of RNA and...

This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $556,697 to the University of Colorado Boulder to improve approaches for predicting molecular crystal properties using generative modeling techniques. The project, led by Professor Michael Shirts, aims to develop machine learning models that can accurately explore molecular conformational ensembles and estimate the thermodynamics of small molecule crystals. This...

Arizona State University received a $418,864 Project Grant award from the National Science Foundation Division of Materials Research to develop techniques for microstructural patterning of thin films using extrinsic seed crystals. The goal is to enable fabrication of metallic alloy films with precisely controlled microstructures to tailor physical and mechanical properties for applications such as computer chips, solar cells, and cutting tools. Under the award, ASU researchers will synthesize...

The National Institute of General Medical Sciences (NIGMS) awarded a $270,929 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to Bellbrook Labs LLC, a limited liability company based in Madison, Wisconsin. The grant will fund the development and validation of a chemically induced dimerization (CID) system capable of detecting nanomolar concentrations of coenzyme A (CoA) in the presence of excess acetyl-CoA. This CID system is intended to provide a...

This Project Grant award from the National Science Foundation (NSF) Engineering Directorate (CFDA 47.041) supports collaborative research to develop scalable nanomanufacturing methods for lead-free perovskite-analogue nanocrystals. The $392,931 project, awarded to North Carolina State University, aims to address critical knowledge gaps in the high-throughput production of copper-based perovskite-analogue nanocrystals using reconfigurable and modular continuous flow reactors. The research...