Project Grant R44GM108259

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,250,000 in funding to Zaiput Flow Technologies LLC, a small business manufacturer based in Waltham, Massachusetts. The award supports the further development of an innovative continuous crystallization device for pharmaceutical manufacturing. The key objectives are to create a scalable, cost-effective, and consistent crystallization process that...

This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) will develop a novel membrane separation technology to address the energy-efficient separation of small molecules from industrial process streams for a range of industries. The $275,000 award to Avanpore LLC, a for-profit limited liability company located in Woburn, MA, will run from October 1, 2024 to March 31, 2025. The project aims to create functionalized...

This Project Grant award from the Department of Energy's (DOE) Office of Science Financial Assistance Program (CFDA 81.049) provides $206,497.00 to CF Technologies, Inc. to conduct research and development on chromatographic separation of rare earth elements. CF Technologies, a for-profit manufacturer and small disadvantaged business, specializes in CO2 extraction, fractionation, separation and chromatography. Through this one-year grant awarded on July 10, 2023, the company will research and...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...

This Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,145,664 to Thermocap Laboratories Inc. to develop a user-friendly, high-throughput, and low-cost differential scanning calorimeter (DSC) instrument for drug discovery and research. The project aims to advance label-free analytical instruments with broad commercial and industrial potential, reducing the complexity and costs associated...

This $306,872 Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) supports the development of a 3D printed integrated sample preparation and chromatography platform for proteomics research at Millennial Materials & Devices Inc., a small disadvantaged business located in Stony Brook, New York. The project aims to fabricate customized 3D printed carbon microbead stationary phase materials and additive manufacturing tools to create an integrated...

This SBIR Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $304,972 to Particle4X, Inc. to develop a real-time, inline sensor system that integrates digital inline holography and deep learning to detect particulate matter and microbial contaminants during injectable drug manufacturing. The system aims to enable continuous quality monitoring, supporting the industry's shift from batch to continuous manufacturing. Key...

This $902,504 cooperative agreement from the National Science Foundation Division of Industrial Innovation under the Engineering program (CFDA 47.041) supports the development of a scalable downstream purification process for gene therapy vectors by Isolere Bio, Inc. of Durham, North Carolina. The non-chromatographic method seeks to address current inefficiencies that lead to single digit yields by utilizing a polypeptide-based reagent combining affinity capture with phase separation and...