This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $1,495,367 to Litron Laboratories LTD to develop a comprehensive hen's egg model for genotoxicity testing. The research aims to create an innovative, metabolically-active in vitro assay that can effectively evaluate the genotoxic potential of pharmaceuticals, chemicals, and other substances without relying on traditional animal models. The project will leverage the unique features of the hen's egg system, including its endogenous metabolism and functioning organ systems, to simultaneously assess genotoxicity in the blood and liver. The research will utilize flow cytometry and high-content imaging to automate the quantification of micronuclei and other biomarkers, providing valuable insights into organ-specific toxicity and genotoxic mechanisms. The project period runs from Aug 10, 2024 to Jul 31, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.2m | 7/23/25 | ||
| Not listed | $295.7k | 8/9/24 |