Mutational profiling in human cells as an in vitro alternative to in vivo mutagenicity assessments
Ended Project Grant Awarded Last action
- Award ID
- R44ES035336
- Recipient
-
Scitovation, LLC UEI MS2HXSWJZJ24 Part of Scimetrika LLC
- Awarding agency
-
National Institute of Environmental Health Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,730,996
Award facts
- Assistance listing
- 93.113 Environmental Health
- Completion date
- Originally
- Place of performance
- North Carolina, USA
Award details come from USAspending.gov.
Description
- Abstract
- Mutations are heritable changes in the cellular genome and are key events in the induction of cancer, birth defects, and neurological diseases. The lack of a mutagenicity bioassay in human cells is a major data GAP in the genetic toxicology test battery used by regulatory agencies for hazard identification and quantitative risk assessments. Scitovation is developing a new approach methodologies (nams) combining human cells and error corrected next generation sequencing as an in vitro alternative to current regulatory mammalian cell mutagenicity assessment using rodent cell lines, and as an in vitro alternative to in vivo mutation assays.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $910,332 | |
| Amendment | $910,332 | |
| Original award | $910,332 |
Quick answers
Who received award R44ES035336?
R44ES035336 was awarded to Scitovation, LLC by National Institute of Environmental Health Sciences (National Institutes of Health) on May 23, 2023.
How much is award R44ES035336 worth?
$2,730,996 has been obligated on R44ES035336.
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