Project Grant R44EB023782

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,149,264 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The University of Texas MD Anderson Cancer Center. The grant, awarded on March 1, 2025 with a final completion date of February 28, 2029, will support the development of a rapid, inexpensive microfluidics-based approach for dose-on-demand production of ready-to-inject...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications. Specifically, the project aims to expand...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $122,260 to the University of North Carolina at Chapel Hill to develop new radiofluorination methods and prosthetic groups for rapid construction of Positron Emission Tomography (PET) tracer analogs. The research aims to facilitate structure-activity relationship...

The National Institutes of Health (NIH) awarded a $375,665 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the University of California, Davis (UC Davis) to install an integrated radiosynthesis system for the production of non-commercially available PET radiotracers for preclinical imaging applications. The system will allow for the automated production of PET radiotracers labeled with fluorine-18, supporting the synthesis of both established and novel radiotracers. The...

This Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $440,287 to GE Medical Systems Information Technologies, Inc. to establish a simplified and accessible procedure for multi-analyte simultaneous extraction of DNA, RNA, and protein from tumor touch imprints. This approach aims to democratize biobanking for low-resource institutes by enabling molecular analysis from smaller tumor samples, including those less than 10,000...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $283,805 to Invizyne Technologies, Inc. to develop a high-throughput platform for engineering enzymes capable of performing "bioclick" group transfer reactions. The platform integrates cell-free protein synthesis with multiplexed mass spectrometry to rapidly screen enzyme variant libraries against diverse substrates. Key...

This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel signal amplification technologies by Molecular Instruments, Inc. to enable automated, ultrasensitive, and multiplex imaging of RNA and protein expression in biological samples. The $1,099,625 award supports the engineering of two key capabilities: 1) a chromogenic signal amplification...

This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development and demonstration of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The innovative platform aims to leverage enzymatic processing and advanced bioinformatics to enable scalable, multiplexed protein sequencing with high accuracy and throughput. During this Phase I...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...