The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $256,501 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Silicon Kidney LLC. The funding supports the development of an Intracorporeal Hemodialysis System (IHEMO) to address mortality disparities among rural and remote end-stage kidney disease patients. The key products and services to be delivered include: Identifying a zeolite material with...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), has awarded a $548,830 Project Grant to Nephsmart LLC in Little Rock, AR. The grant, awarded on August 1, 2024, with a completion date of July 31, 2025, will support the development and testing of a point-of-care device to predict the risk of severe acute kidney injury (AKI). The device will detect cleavage of a specific...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a catheter end cap with an antimicrobial luminal insert to reduce the risk of bloodstream infections in hemodialysis patients. The $591,844 award to Allvivo Vascular, Inc. will fund the development, manufacturing, and testing of the "Gatekeeper Antimicrobial Barrier...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $238,184 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The project, titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS", aims to develop an in vitro microphysiological system (MPS) that can recapitulate and control the...
The federal Project Grant award R01DK139139, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a biomechanocompatible small molecule-releasing scaffold for bladder augmentation. The $708,138 award, with a period of performance from December 2024 to November 2028, will support research to promote bladder tissue regeneration without the use of exogenous...
This $337,284 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support the development of a novel "Precision-Cut Bladder Slice" (PCBS) technology at Boston Children's Hospital. The goal is to enable quantitative assessment of bladder smooth muscle contraction, relaxation, and stiffness in both healthy murine and human tissues, while...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides USD 658,800 to The Research Foundation For The State University Of New York to conduct research on the urothelial glycosaminoglycan (GAG) layer and its role in catheter-associated urinary tract infections (CAUTIs). The key objectives of the research project are to: Comprehensively examine...
This $577,420 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to provide a mechanistic framework for understanding the physiology of the upper urinary tract. The research, conducted by Weill Medical College of Cornell University, will use a novel mouse model to define the transcriptional signaling mechanisms and protein complexes required for...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $499,890 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Pavaj Vascular Corporation in Rochester, MN. The funding will support the development and evaluation of a novel therapy to prevent venous stenosis and neointimal hyperplasia in arteriovenous fistulas used for hemodialysis in patients with end-stage kidney disease. The project aims to 1) assess the stability...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $299,999 Project Grant (CFDA 93.847) to Hibar Microsciences, LLC to develop a prototype for CLEAR, a novel hemodialysis cartridge designed to improve the clearance of protein-bound uremic toxins (PBUTs) from the blood of patients with end-stage renal disease. The key objectives are to: 1) Develop a method for immobilizing lipocalin proteins onto dialysis membrane matrices to enhance PBUT removal; 2) Create and...