Project Grant R44DK124085

This $100,000 National Science Foundation Technology, Innovation, and Partnerships grant funds the development of tunable porosity aerogel for wound care dressings at The University of Akron from July 1, 2022 to June 30, 2023. The project aims to create a novel bio-based aerogel dressing that could help heal patients with chronic wounds faster by requiring fewer dressing changes. Aerogels' high porosity, surface area and moisture balance properties may create an incubator-like wound healing...

This Project Grant award of $597,683, funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), supports the development and evaluation of an injectable, self-powered piezoelectric nanocomposite hydrogel scaffold to promote the healing of major, load-bearing cartilage defects in large animal models. The proposed work aims to create an...

This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Auxilium Health, Inc. to develop an aerogel-based wound dressing material with integrated fluid management, biofilm prevention, and infection detection capabilities. The key products and services to be delivered under this 1-year award include: Optimizing the aerogel material's pore structure to effectively prevent bacterial...

This federal Project Grant award, issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $687,416 to Lynntech Inc. to develop a cutaneous gel that can controllably deliver a small molecule therapeutic to effectively address impaired wound healing in diabetic foot ulcers (DFUs). The key objectives are to: (1) prepare, characterize, and select a preferred gel...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $295,000 to Biodynamik, a for-profit organization, to develop a novel implantable system that leverages distraction osteogenesis as a treatment for diabetic foot ulcers (DFUs). The objectives of this Phase I SBIR project are to complete the design and development of a low-profile implantable transverse tibial transport device that can...

This $100,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of an advanced wound care technology at Florida International University. Specifically, the university will create a bandage-integrated platform that provides feedback-mediated wound therapy to enable personalized care. The conformable platform is designed to non-invasively monitor multiple wound biomarkers in spatial detail and then apply targeted...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development of an optimized, off-the-shelf alternative to autologous fat grafting for soft tissue repair. The $293,983 award to Insoma Bio, Inc., a biotechnology company in Durham, North Carolina, will evaluate the combination of Insoma Bio's Fractomer tissue repair matrix and the Renuva adipose allograft material from MTF...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $1,617,565.00 to New York University (NYU) to develop a modular toolbox of protein and lipid hybrid biomaterials for the delivery of short interfering RNA (siRNA) sequences. The goal is to construct a hybrid nanovehicle, termed a lipoproteoplex (LPP), that can...

This federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to develop a novel therapeutic approach to improve angiogenesis and wound healing by delivering apoptotic neutrophils within a degradable hydrogel scaffold. The $172,700 award, effective August 20, 2024 through July 31, 2026, supports research to investigate the effects of the hydrogel-apoptotic neutrophil delivery on macrophage angiogenic signaling and its impact...