This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,930,758 to Sylvatica Biotech Inc., a minority-owned small business, to develop novel techniques for "enhanced supercooling" to enable ice-free preservation of clinical-scale livers at high subzero temperatures for over 72 hours. The goal is to significantly extend current liver preservation times...
This federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) provides $199,867 to the University of Washington to develop an innovative approach for long-term cryopreservation of organs using ice-free vitrification and single-mode electromagnetic resonance (SMER) heating. The project aims to overcome barriers in organ cryopreservation by advancing vitrification and EM heating technologies to enable fast and uniform rewarming of cryopreserved...
The Regents of the University of California, San Francisco (UCSF) received a $550,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an advanced cryopreservation system for complex bioengineered tissues. The project aims to determine the thermodynamic and biological parameters needed for isochoric supercooling cryopreservation of three-dimensional tissues within a microgravity-optimized...
This federal Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $940,821 to Cryocrate LLC, a for-profit biotech company based in Columbia, Missouri, to develop a first-in-class biocompatible and efficient cryopreservation technology platform for cell-based therapeutics in regenerative medicine and drug discovery. The key objectives of this project are: (I) Producing the company's proprietary Odinsol cryopreservation medium...
Cornell University was awarded a $500,000 Project Grant from the United States Department of Agriculture National Institute of Food and Agriculture under the Agriculture and Food Research Initiative competitive grants program. The four-year project aims to advance cattle genetic improvement through cryopreservation technology by studying the effects of cooling rates on ice crystal formation in embryos and developing next-generation cryopreservation methods. Specifically, the university will...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $302,037 to Tissue Testing Technologies LLC to develop an ice-free vitrification and nanowarming method for preserving meniscal grafts used in transplantation. The project aims to optimize nanowarming techniques to maintain cell viability, gene expression, and extracellular matrix integrity...
This $1,088,500 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) was granted to The Washington University in St. Louis to pioneer a platform technique that uses ultrasound to noninvasively and safely induce artificial hibernation in mammals. The overarching goal is to develop a disruptive medical innovation that can enhance human health by harnessing the physiological benefits of natural...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $275,739 project grant under the Cardiovascular Diseases Research (CFDA 93.837) program to WR Biotech, LLC, a small disadvantaged business. The grant supports research on a novel technique called Improved Synchronization Modulation Electric Field (I-SMEF) to protect donor hearts and improve transplanted heart graft function during cold storage prior to heart transplantation in mice. The I-SMEF technique aims to maintain...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $306,852 to Mitegen, LLC, a manufacturer of advanced scientific instruments and technologies located in Lansing, New York. The funding will support the development and validation of innovative cryopreservation technology that automates the soaking, cooling, and warming processes for small biological samples such as oocytes and...
The National Science Foundation awarded $275,000 under the Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to Kazadi Enterprises LTD to develop a Hydrologic Open Cooling System. The project aims to create a renewable, closed container cooling system incorporating rechargeable vacuum insulation and a novel two-stage heat pump. The system is designed to maintain cooling chamber temperatures between 1.5-5 degrees Celsius using 10% or less of the electrical power of...