The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $613,736 Project Grant to Cayman Chemical Co Inc. to develop novel osteogenic small-molecule pharmacotherapies for local delivery that stimulate alveolar bone regeneration. The goal is to address the clinical need for improved treatments for periodontitis-related bone resorption, especially in aging populations. The project leverages Cayman...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,196,355 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Regendodent, Inc. in Ann Arbor, Michigan. The grant will fund the development of RegendoGel (RG), a new class of dental material that stimulates regeneration of dental pulp and dentin damaged by decay or trauma. The project aims to compare an RG formulation using bovine-derived materials to one using porcine-derived materials, as well as...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,029,497 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oridivus LLC located in Decatur, Georgia. The purpose of this grant is to compare the efficacy of FTY720 nanofibers versus platelet-rich plasma (PRP) in improving oral wound healing in rodent and porcine animal models. The goal is to develop an immunoregenerative approach to enhance oral wound healing, which is a significant...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $591,378 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Callentis Consulting Group LLC, a woman-owned small business. The grant supports the development of high-performance, bisphenol A (BPA)-free dental restoration composites with remineralization capabilities. The research, conducted in collaboration with the University of Colorado and New Mexico State University, aims to...
This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,849,232.90 project grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a period of performance from September 1, 2024 to May 31, 2028. The goal of this project is to identify the cellular and molecular identity of genes and pathways defining dental mesenchymal cell differentiation and fate early in tooth...
The Project Grant award of $306,633.00 was granted by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, to Ther-Ai LLC. The purpose of this award is to develop CRANIAMAP, a software suite that provides auto-segmentation and landmark digitization capabilities for cone beam computed tomography (CBCT) scans. This technology is intended to enhance precision and efficiency in orthodontic,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
This $499,440 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to develop and evaluate novel dental restoration materials that are more durable and have enhanced antimicrobial, protein-repellent, and therapeutic properties compared to existing methacrylate-based resin composites. The key objectives are to formulate biostable hybrid resin networks, incorporate multifunctional...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,695,557 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to VIC Foundry Inc. The grant supports the commercialization of VITAL-DENT, a hydrogel-based regenerative pulp therapy for dental applications. The project aims to scale up manufacturing, optimize the formulation, and demonstrate the effectiveness and biocompatibility of VITAL-DENT to support FDA clearance. VITAL-DENT is...