Project Grant R44DE033312
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,178,476 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Oraliva, Inc., a technology company in Durham, North Carolina. The purpose of this 2-year project, with a completion date of March 31, 2027, is to develop an AI-linked cytomics-on-a-chip technology to enable near real-time identification and management of oral lichenoid lesions in primary care settings. This...
- This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...
- This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $1,021,347 to Vigilant Laboratories LLC to develop a low-cost, point-of-care early detection test for oral cancer in low-resource settings. The key products to be delivered include: Prototypes of test strips for three biomarkers (CD44, total protein, and p16) to enable a commercializable point-of-care test. Vigilant Laboratories will work with a manufacturing partner,...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,277,806 Cooperative Agreement under the Oral Diseases and Disorders Research (CFDA 93.121) program to The Washington University to validate a novel prognostic biomarker for oropharyngeal cancer (OPC). The project aims to validate a biomarker called HPVHET that captures tumor biology and heterogeneity in over 1,000 diverse human papillomavirus-positive (HPV+) OPC patients. The goals are to analytically validate the...
- The National Cancer Institute (NCI) awarded Oraliva, Inc. a $400,000 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop a novel, low-cost, and fully integrated point-of-care (POC) gynecological screening test. The grant, awarded on September 1, 2025, with a completion date of August 31, 2026, will enable Oraliva to leverage its proprietary AI-linked cytomics-on-a-chip technology (ONC-INCYT) to create a rapid, POC diagnostic tool that can accurately...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $716,123 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida. The grant, awarded on September 8, 2025, aims to establish a clinical cohort and develop novel analytical methodologies to validate, discover, and optimize non-invasive liquid biopsy tests for prognosis prediction in head and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $219,660 Project Grant to the Regents of the University of Michigan to conduct research on "Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer". This project aims to investigate how myeloid cells in precancerous lesions develop suppressive phenotypes that inhibit anti-tumor immune...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...
- This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,414,853 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Innotech Precision Medicine, Inc., a woman-owned small business, to develop RECOGNIZE-OPSCC. This saliva-based, point-of-care diagnostic test aims to provide rapid, non-invasive, and accurate detection of oropharyngeal squamous cell carcinoma (OPSCC). The project integrates an AI-enabled, ultraportable device with an FDA-approved saliva collection device and a disposable diagnostic cartridge to simultaneously detect genotypic (HPV16, HPV18) and phenotypic markers of OPSCC. The key objectives are to optimize the device's optical detection system, validate the test's accuracy using clinical specimens, and evaluate the stability of the lyophilized reagents. This innovation aims to establish RECOGNIZE-OPSCC as a reliable alternative to biopsy, enabling early detection and timely treatment of OPSCC to improve patient outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/28/25 | ||
| Not listed | $1.4m | 8/8/25 |