Project Grant R44DC018759

This federal Project Grant award of $307,962 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the CFDA program "Research Related to Deafness and Communication Disorders" supports the development of a non-invasive, therapeutic hypothermia treatment for tinnitus. The primary objective is to test the efficacy of localized mild therapeutic hypothermia (MTH) in providing symptomatic relief and reducing the severity of tinnitus, a debilitating condition...

The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $305,995 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to Auricle, Inc., a small business in California. The grant supports the development of a novel in-home neuromodulatory medical device to treat the underlying cause of tinnitus, a prevalent and debilitating condition affecting up to 50 million Americans, including 3 million veterans. The project aims...

The University of Rochester received a $145,989 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) to conduct research on the "Cortical Mechanisms Underlying Aberrant Auditory Perception". The 5-year project, which began on May 1, 2025, will utilize animal models and in vivo imaging techniques to determine whether altered cell-specific activity or disrupted neurotransmitter signaling in the auditory and frontal cortices underlie...

This $610,394 Phase I STTR project, awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), aims to develop a novel, single-use, navigable endovascular medical device called PHONOCATH to objectively evaluate pulsatile tinnitus. The project is led by VDF Industries, in collaboration with the University of California, San Francisco (UCSF). The key objectives are to design and...

This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $275,737 to Rewire Neuroscience LLC to develop and validate a machine learning platform for predicting the ototoxic potential of pharmaceutical compounds. The key objectives are to: 1) optimize and apply an innovative machine learning model that can categorize drugs as ototoxic or...

This $610,725 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) supports research into the physiological mechanisms underlying suprathreshold deficits in sensorineural hearing loss. The project, titled "Physiological Determinants of Suprathreshold Deficits in Sensorineural Hearing Loss," will be conducted by researchers at the University of Pittsburgh from May 2, 2025 to April 30, 2030. The key objectives are to: 1) Characterize the...

This $369,806 Project Grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into objective screening tests for noise-induced hearing damage. The University of Wisconsin-Madison will investigate short- and long-term changes in cochlear, afferent, and efferent auditory system function due to noise exposure using otoacoustic emission-based assays of the middle ear muscle reflex and medial olivocochlear reflex....

The federal Project Grant award of $581,105.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, supports research to develop natural-based therapies for sensory disorders, particularly aminoglycoside-induced hearing loss. The primary awardee, Creighton University, will 1) design and test piperlongumine derivatives with improved properties for targeting the TRPV1 channel, 2)...

This $428,883 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) aims to examine the effects of individualized transcranial alternating current stimulation (tACS) on phonological short-term memory performance in chronic stroke survivors with aphasia. The key objectives are to identify optimal tACS targets, frequency, and electric field coverage based on...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $589,483 to Wayne State University to assess in vivo changes in central neuronal activation, molecular indicators of synaptic transmission, and motor function in response to vestibular nerve hypofunction generated by noise exposure. The project aims to evaluate the contributions of...