Project Grant R44CA295189
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $400,000 to Kure Ai Inc. to develop a novel CAR-T cell therapy product targeting the MR1 antigen expressed on the surface of various tumor cells, including acute myeloid leukemia (AML) and glioblastoma. The key objectives are to: 1) assess MR1 expression in primary patient AML and glioblastoma samples, 2) perform mouse efficacy studies using AML and glioblastoma models, and 3)...
- This $1,340,987 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Koi Biotherapeutics Inc. aims to revolutionize chimeric antigen receptor (CAR) T-cell therapy by developing a novel CAR-enhancer platform to improve the functionality and persistence of CAR T-cells. The key products and services to be delivered under this 2-year project include: Optimization of dosing and timing for CAR-enhancer administration in a Phase I clinical trial to enhance...
- The National Cancer Institute (NCI) awarded a $400,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) to Lifengine Animal Health Laboratories Incorporated. The purpose of this Phase I grant is to demonstrate the feasibility of producing chimeric antigen receptor (CAR)-T cells that overexpress the transcription factor C-MYB to enhance their anti-tumor activity and limit functional exhaustion. Lifengine will leverage its proprietary GeneWeld gene editing platform to...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $2,253,869.00 to Celdara Medical, LLC to develop CM-HZ01, a novel non-alpha IL-2 therapeutic for the treatment of metastatic melanoma. The funding will advance CM-HZ01 to Investigational New Drug (IND) status, with the goal of providing a best-in-class immunotherapy option for patients with limited effective treatment options for this deadly form of skin cancer. The project aims...
- This federal Project Grant award of $400,000 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports the advancement of next-generation CAR-T cell therapies for renal cell carcinoma (RCC). The award recipient, Cellinfinity Bio Inc., is developing novel CAR-T cell modifications, including a PRDM1 exon 3 knockout and a CTLA-4 cytoplasmic tail fusion, to enhance CAR-T cell efficacy against RCC tumors. The project aims to evaluate the combination of these...
- The federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) will support a Phase 2 multi-center clinical trial of an innovative CD5 chimeric antigen receptor (CAR) T-cell therapy (MB-105) developed by March Biosciences Inc. for the treatment of relapsed/refractory T-cell lymphoma (R/R TCL). The $1,124,607 award, with a project period from July 1, 2025 to June 30, 2027, will fund the continued evaluation and advancement of this novel...
- The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), awarded a $314,685 Project Grant to Persistence Therapeutics, Inc. under the Cancer Treatment Research program (CFDA 93.395). The grant supports the development of a novel CAR T cell therapy approach called "SynthNode" - an implantable device that mimics the function of a synthetic lymph node to produce potent, persistent CAR T cells for improved cancer treatment outcomes. The 1-year project aims to...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $399,958 to Mabswitch Inc., a minority-owned small business, to assess the feasibility of regulating the activation, effector functions, and cytokine release of chimeric antigen receptor (CAR) T-cell therapies. The project aims to develop a "switchable affinity CAR" (SAEFCAR) that can be controlled by an exogenously administered ligand, potentially mitigating the toxicity...
- The National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) awarded a $399,444 Project Grant to Cancure LLC (DBA Canzx Biotherapeutics) to conduct a feasibility study of a novel NK and CD8 T cells stimulating agent. The project aims to develop a complex molecule that can be used as an additive during NK and antigen-specific CD8 T cell expansion to enable their superior efficacy in treating solid tumors. The key objectives are to address the challenges of persistence and...
- The federal Project Grant award for $400,000.00 from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), supports the development of an innovative approach to point-of-care autologous chimeric antigen receptor (CAR)-T cell manufacturing. The project, awarded to Aerocytek, Inc., a self-certified small disadvantaged business in California, aims to leverage targeted microbubble-based technologies to streamline and overcome the challenges in integrating...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $1,313,567 to Cytoagents Inc. to develop CTO1681, a compound for preventing and treating cytokine release syndrome (CRS) in multiple myeloma patients receiving CAR T-cell therapy. CRS is a dangerous adverse event associated with this emerging cancer treatment. Cytoagents is conducting preclinical research to demonstrate CTO1681's ability to modulate the release of inflammatory cytokines and mitigate CRS. The research aims to prepare CTO1681 for investigational new drug (IND) application and subsequent clinical trials, with the goal of improving patient outcomes for those receiving CAR T-cell therapy. The project period runs from September 2025 to August 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/19/25 |