This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $1,220,394 to the Sloan-Kettering Institute for Cancer Research to conduct comprehensive molecular and clinical characterization of acute and chronic neurotoxicity following CAR-T cell therapy. The research aims to investigate the pathogenesis of acute immune effector cell-associated neurotoxicity syndrome (ICANS) and assess neurocognitive function and neuroimaging outcomes in...
This $1,013,623 Project Grant awarded by the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) to March Biosciences Inc. aims to develop dual-targeting chimeric antigen receptor (CAR) T-cell therapies for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma (TCL). The grant will fund the development of CD5/CD7.CAR-T cells derived from haploidentical, CD45RA-depleted donor T-cells (RAD-T) to target malignant T-cells with varying antigen expression....
This $1,477,396 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to develop an innovative approach to enhance the efficacy and durability of CD19-targeted CAR T-cell therapy for B-cell non-Hodgkin's lymphoma (B-NHL). The key elements include: Selecting cytomegalovirus (CMV)-specific T cells for modification with a CD19-targeting CAR, and then infusing the resulting bi-specific CMV-CD19 CAR T cells into patients. Inducing expansion of the...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $400,000 to Kure Ai Inc. to develop a novel CAR-T cell therapy product targeting the MR1 antigen expressed on the surface of various tumor cells, including acute myeloid leukemia (AML) and glioblastoma. The key objectives are to: 1) assess MR1 expression in primary patient AML and glioblastoma samples, 2) perform mouse efficacy studies using AML and glioblastoma models, and 3)...
This federal Project Grant award of $513,859, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research to develop a novel adoptive cellular therapy platform using hematopoietic stem cells (HSCs) engineered with chimeric antigen receptor (CAR) technology. The goal is to generate a continuously renewing population of CAR-expressing natural killer (NK) cells that can provide long-term, safe, and efficacious anti-cancer immunity. The research aims to...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $399,958 to Mabswitch Inc., a minority-owned small business, to assess the feasibility of regulating the activation, effector functions, and cytokine release of chimeric antigen receptor (CAR) T-cell therapies. The project aims to develop a "switchable affinity CAR" (SAEFCAR) that can be controlled by an exogenously administered ligand, potentially mitigating the toxicity...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $665,000 to support the development and clinical testing of MT-601, a novel multi-tumor associated antigen (MTAA)-specific T-cell therapy for the treatment of non-Hodgkin lymphoma (NHL). The key objectives of this project are to manufacture the MT-601 product and conduct a Phase 1 clinical trial evaluating its safety and efficacy in NHL patients who have relapsed after prior CD19...
This federal Project Grant award for $1,108,391.72, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research at The Leland Stanford Junior University to define the optimal characteristics of chimeric antigen receptor (CAR) T cells for the treatment of large B-cell lymphoma (LBCL). The key research goals are: (1) to identify the most therapeutically relevant CAR T cell subsets in LBCL patients, and (2) to overcome immune suppression by CAR T...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides funding to Luminary Therapeutics, Inc., a self-certified small disadvantaged business, to develop an innovative chimeric antigen receptor (CAR) T-cell therapy targeting epithelial ovarian carcinoma. The $798,512 award, with a project period from September 2024 to August 2025, supports the development of an "armored split CAR" T-cell product that combines two CAR molecules...
This Project Grant award from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) provides $748,337 to Pyrojas Inc. to develop "Pyrotimer CAR-T cells" - an innovative approach that aims to inhibit the TGF-beta pathway and enhance the persistence and cytotoxicity of CAR-T cell therapies within the immunosuppressive tumor microenvironment. The key objectives are to: 1) Decipher the influence of TGF-beta on Pyrotimer CAR-T cells, 2) Profile cytokine...