Intraoperative stereovision for surgical guidance
Ended Project Grant Awarded Last action
- Award ID
- R44CA239843
- Recipient
-
Insight Surgical Technologies Inc. UEI RUHKJWW84LK4
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,814,305
Award facts
- Assistance listing
- 93.393 Cancer Cause and Prevention Research
- Completion date
- Originally
- Place of performance
- Lyme, NH 03768, USA
Award details come from USAspending.gov.
Description
- Abstract
- Insight surgical technologies, LLC, is a start-up founded by senior members of a long-standing NIH-funded research effort to develop intraoperative image updating that maintains accurate image correspondence with the surgical field throughout a procedure. The effort has led to research innovations that have generated an intellectual property (IP) portfolio of 13 issued and 8 pending patents. Phase i demonstrated feasibility of new algorithms for assembling multiple intraoperative stereovision (ISV) acquisitions into a composite field-of-view and accomplishing ISV-to-MRI registration/RE-registration, and conversion of existing ISV algorithms for 3D surface reconstruction and calibration in graphics processing unit (GPU) accelerated forms. Additionally, phase i results obtained during resection of a large animal (swine) brain tumor indicate this model is a superb system for testing and validating insight's complete image updating system, I2UPDATETM, in vivo in phase II. Specifically, we will leverage phase i results to automate I2UPDATETM fully, and demonstrate its technical performance and clinical functionality under quality systems sufficient to meet regulatory requirements. Specific aims will (i) develop a fully-automated, GPU-enabled processing system for intraoperative image-updating (I2UPDATETM), (II) complete verification testing and pre-clinical in vivo validation of I2UPDATETM, under quality system controls sufficient for supporting regulatory filings at the end of phase II, and (III) conduct a multi-site clinical-use study with I2UPDATETM under non-significant risk in patients undergoing brain tumor resection. Successful completion of phase II will produce the I2UPDATETM product platform as a finalized commercial GPU-enabled software system with concomitant design control, software validation, procedural use and quality systems, accompanied by in vivo animal validation and multi-site, multi-surgeon use demonstrating clinically- relevant and acceptable image-updating performance in terms of automation, computational efficiency and registration accuracy.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | -$185,487 | |
| Amendment | $185,487 | |
| Amendment | -$185,487 | |
| Amendment | $185,487 | |
| Amendment | -$185,487 | |
| Amendment | $185,487 | |
| Amendment | -$185,487 | |
| Amendment | $1,085,184 | |
| Amendment | $1,085,184 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $914,712 | |
| Original award | $914,712 |
Show all 16
Quick answers
Who received award R44CA239843?
R44CA239843 was awarded to Insight Surgical Technologies Inc. by National Cancer Institute (National Institutes of Health) on July 1, 2019.
How much is award R44CA239843 worth?
$3,814,305 has been obligated on R44CA239843.
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