Project Grant R44CA134031

The federal Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research Program (CFDA 93.394) provided $1,164,814 to O2M Technologies LLC to develop an advanced imaging system using pulse electron paramagnetic resonance (PEPR) techniques. The goal is to create a fast and precise method for measuring partial oxygen pressure (pO2) in tissues, which can guide cancer treatment and other medical applications. The project involves establishing the hardware for...

The National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) awarded Cordance Medical Inc. a $999,125 Project Grant on September 11, 2025 to develop the "NeuroAccess" system, a focused ultrasound device designed for safe, temporary, and non-invasive blood-brain barrier (BBB) opening. This technology enables a novel liquid biopsy technique called "sonobiopsy" to improve the clinical management of malignant brain tumor patients by providing timely...

This $399,358 Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to Cordance Medical Inc. aims to optimize a non-invasive focused ultrasound system, called the "NeuroAccess System," to enable liquid biopsies for brain tumor patients. The key objectives are to demonstrate the safety of repeatedly opening the blood-brain barrier, optimize the opening volume and technique in a rat glioma model, and confirm the system's ability to...

The U.S. National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $349,908 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Evanesc Therapeutics, Inc. to develop a non-invasive medical device designated "EvaPERMEA" that uses low-power radio frequency evanescent waves to temporarily permeabilize the blood-brain barrier. This innovation aims to improve the delivery of therapeutic...

The National Cancer Institute (NCI) awarded a $400,000 Project Grant under CFDA 93.394 (Cancer Detection and Diagnosis Research) to O2M Technologies LLC to develop a Multifunctional Imager (MFI) that can simultaneously acquire tissue oxygen pressure (pO2) and pH maps using electron paramagnetic resonance imaging (EPRI) techniques. The 12-month project aims to create a 25 MT Halbach-type permanent magnet, new multi-modal transmit-receive electronics, and the integrated MFI instrument. This...

This $1,336,000 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the CFDA 93.286 "Discovery and Applied Research for Technological Innovations to Improve Human Health" program supports the development of a rapid, motion-robust, and low-gadolinium MRI technology for pediatric brain tumors. The key objectives are to (1) develop cutting-edge technologies for rapid, motion-robust, and quantitative MRI scans to reduce sedation needs...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is focused on developing a next-generation photoacoustic computed tomography device for non-invasive monitoring of brain oxygen metabolism. The $249,000 award, spanning July 2025 to June 2028, aims to design, fabricate, and validate a handheld photoacoustic imaging device that...

The National Science Foundation awarded $256,000 to Optave Diagnostics LLC through the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a prototype endoscopic probe for molecular imaging and diagnosis of cancerous prostate pathologies. The 12-month project grant will support the creation of a medical device using photoacoustic imaging and acoustic lens technology to aid in the detection and diagnosis of prostate cancer. The proposed endoscopic probe offers an alternative...

The National Science Foundation awarded a $266,000 Project Grant to Columbia University under the NSF Technology, Innovation, and Partnerships federal grant program (CFDA 47.084) to develop a wearable noninvasive brain imaging device using near-infrared light-based time-domain diffuse optical tomography. The device aims to improve clinical outcomes in neurology by enabling measurement of deep brain blood flow, which is difficult to measure with current technologies. The grant will support...

This $1,296,385 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to accelerate the translation and commercialization of a novel, non-invasive wearable rotating magnetic field therapy device (ONCOMAGNETIC DEVICE or OMTX) targeting the treatment of brain cancers. The device generates spinning oscillating magnetic fields that have demonstrated strong, selective anti-cancer effects on patient-derived glioblastoma (GBM) cells and...