Project Grant R44AR076301

This Project Grant award, made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of Dermisphere, an advanced dermal regeneration scaffold product by Fesariustherapeutics Inc. The $349,345 award aims to demonstrate the feasibility of using Dermisphere to manage acute major burn wounds. Preliminary studies have shown that Dermisphere can support rapid and sustained cellular...

The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $349,892 project grant to Fesariustherapeutics Inc. to develop Dermisphere Shield, an antimicrobial dermal regeneration template for application in challenging wound environments. The project aims to create a dermal regeneration scaffold that promotes rapid cellular infiltration, angiogenesis, and accelerated wound healing, potentially offering...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded Collamedix Inc. a $300,000 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to establish the feasibility of their "CollaLink" collagen-based scaffold for augmenting primary repair of anterior cruciate ligament (ACL) mid-substance tears. The project aims to demonstrate that the CollaLink scaffold, when placed around an ACL tear, can provide a...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting the development of an optimized, off-the-shelf alternative to autologous fat grafting for soft tissue repair. The $293,983 award to Insoma Bio, Inc., a biotechnology company in Durham, North Carolina, will evaluate the combination of Insoma Bio's Fractomer tissue repair matrix and the Renuva adipose allograft material from MTF...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,952,000 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to Matregenix Inc., a small disadvantaged business located in California. The grant supports the development of MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. The research aims to create a membrane with a unique...

The University of Pennsylvania was awarded a Project Grant by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a multicomponent hydrogel system that can spatiotemporally activate Wnt and Sonic Hedgehog signaling pathways to promote hair follicle neogenesis and scarless wound healing. The $1 project grant was awarded on Aug 6, 2025 and is scheduled for completion by Jul 31, 2030. The proposed...

This $672,394.58 project grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research Oral Diseases and Disorders Research program (CFDA 93.121) supports the development of a crosslinkable tissue particle implant for regenerating craniofacial bone. Led by Leefa Biotech LLC, the one-year award aims to demonstrate improved bone regeneration in critical-size cranial bone defects using the implant compared to the current standard of care. If successful, the...

The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $913,000 Project Grant to the University of Southern California to support research on periodontal regeneration using supramolecular nanomaterials. The project aims to identify biologically active peptides, specifically the leucine-rich amelogenin peptide (LRAP), that can stimulate the differentiation of periodontal ligament cells...

This federal Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to develop a bio-inspired scaffold (PerióPatch) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research aims to integrate biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and the formation of well-aligned PDL principal and...

This $516,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of injectable cellulose-based hydrogels for soft tissue bulking from July 1, 2022 to June 30, 2024. The Research Foundation of the City University of New York, in partnership with the City University of New York, will engineer a stable yet reversible injectable soft tissue filler material derived from plant polysaccharides like cellulose. If successful,...