Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scribe Biosciences, Inc. a $300,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a high-throughput antibody discovery platform against cell membrane-bound proteins. Scribe Biosciences, a for-profit company specializing in microfluidics and biomedical engineering, will utilize its proprietary Microenvironment on Demand (MOD) technology to assemble over 100,000...
This $1,500,314 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to engineer a hydrogel-based human immune organoid inspired by lymphoid tissues. The goal is to generate antigen-specific germinal center B cells and high-affinity antibody-secreting plasma cells ex vivo, and evaluate the in vivo engraftment of the engineered human B cells delivered through injectable gels. The 5-year project,...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $273,550 to Biocognon LLC provides funding to develop a novel yeast-based high-throughput screening platform for efficiently generating molecular recognition domains that can specifically recognize clinically important targets. The goal is to integrate breakthroughs in next-generation DNA sequencing, synthetic biology, and computational biology to create a combinatorial...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $303,024 to Biocognon LLC to develop an innovative combinatorial nanobody discovery platform. The key objectives are:
Develop a robust 4-piece Golden Gate assembly system leveraging validated yeast secretion and display vectors to efficiently assemble GPCR/nanobody libraries with high complexity.
Build a fully...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is developing a microfluidic device for rapid and inexpensive pathogen detection in rodent animal health surveillance. The goal is to create a device that can be used cage-side to complement existing quarterly room/rack monitoring, enabling faster outbreak mitigation and health status confirmation for animal importation. The key...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $807,664 to Heligenics, Inc. to develop a high-throughput screening platform for identifying novel bifunctional protein chimeras as potential biologic drug candidates.
The key objectives of this 3-year project are to: 1) Evaluate a library of over 50,000 bifunctional interferon chimeras to isolate more active...
The federal Project Grant award R01AI182177, with a total funding of $1,574,412.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to develop "armed nanobodies" as therapeutic agents against viral infections and cancer. Key objectives include:
Investigating the relative contributions of antibody-dependent cell-mediated cytotoxicity (ADCC) and...
This Project Grant award, with a total funding amount of $727,273, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The goal of this 5-year project is to develop a low-cost, point-of-care diagnostic tool for tuberculosis (TB) by leveraging novel approaches to rapidly and accurately profile antibody signatures associated with active TB disease. Key products to be delivered include:
A...
This $273,644 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports the development of synthetic RNA-based sensors, termed "encrypted RNA" (EncRNA), to enable high-throughput, quantitative screening for discovering new classes of broad-spectrum antiviral therapeutics. The goal is to create a versatile platform that can democratize broad-spectrum...