3STEP: a swab-seal-read assay for tuberculosis and RIF resistance enabled by autonomous extraction technology
Active Project Grant Awarded Last action
- Award ID
- R44AI179588
- Recipient
-
Salus Discovery LLC UEI YJ6CYLKZ4JL9
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,209,598
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 77% complete
- Originally
- Place of performance
- Madison, WI 53703, USA
Award details come from USAspending.gov.
Description
- Abstract
- In 2021 there were 10.6 million new cases of mycobacterium tuberculosis (TB) and 1.6 million TB-related deaths, making TB the second leading infectious cause of death worldwide behind only covid-19. Standard TB diagnostic methods are insufficient in that they either 1) utilize challenging sample types and are often invasive (e.g., sputum, gastric aspiration, lymph node biopsy), 2) lack sufficient sensitivity and/or specificity (e.g., culture, reliance on clinical observation alone), or 3) cannot be widely implemented in community point-of-care (POC) settings. As a result, there remains a significant unmet need for affordable POC technologies that can be used at local or temporary clinics, urgent care facilities, pharmacies, and school health clinics with easier to acquire samples (e.g., urine or oral swabs). In addition, TB is notoriously difficult to lyse adding another challenge to the creation of a POC solution. Salus discovery has developed 3STEP, a new lamp-based POC NAT for TB that directly overcomes the above mentioned challenges. 3STEP provides lab-quality, PCR sensitivity (
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $913,705 | |
| Amendment | $0 | |
| Amendment | $1,000,000 | |
| Amendment | $1,000,000 | |
| Original award | $295,893 |
Quick answers
Who received award R44AI179588?
R44AI179588 was awarded to Salus Discovery LLC by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on June 25, 2024.
How much is award R44AI179588 worth?
$3,209,598 has been obligated on R44AI179588.
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