Project Grant R44AI172565
- Federal Cooperative Agreement Summary Insectapel LLC received a $1.05M Cooperative Agreement award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships program (CFDA 47.084) on September 15, 2025, with completion targeted for August 31, 2027. The award funds Phase II Small Business Innovation Research (SBIR) development of bio-based, non-toxic insect-repellent textiles designed to protect against biting insects such as mosquitoes and biting flies. The...
- Federal Grant Award Summary Texas A&M Agrilife Research received a $423,106 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award supports research to characterize the role of tick metalloprotease inhibitors in the transmission of Borrelia burgdorferi, the causative agent of Lyme disease, by blacklegged nymphal ticks. The research...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant under the NSF Technology, Innovation, and Partnerships (TIP) program to the University of California, Los Angeles (UCLA) to develop a rapid, multiplexed diagnostic tool for serological testing of tick-borne diseases (TBDs). This 2-year project seeks to improve blood-based detection of TBDs, including Lyme disease, Babesia, Anaplasma, and relapsing fever, through an innovative point-of-care (POC) serological assay. The goal is...
- The University of Maine System has been awarded a $2,021,000 Cooperative Agreement from the Environmental Protection Agency Office of Research and Development under the Congressionally Mandated Projects program (CFDA 66.202). The goal of this 4-year project is to examine how climate change impacts the seasonality and life cycle of ticks, a key vector for disease transmission. Key activities include: 1) researching the molecular and hormonal factors regulating tick diapause in relation to climate...
- Federal Grant Award Summary Athena Vector Technology LLC received a $330,363 Project Grant from the Medical Command (Defense) under the Pest Management and Vector Control Research program (CFDA 12.355) on January 5, 2026. The award supports research and development activities through January 4, 2029, focused on commercializing a mechanical mode of action insecticide designed for effective tick and arthropod control. The primary deliverable is a product-oriented insecticide solution intended to...
- The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) has awarded a $179,544 project grant to the Cary Institute of Ecosystem Studies, Inc. in Millbrook, NY. The funding will support research to evaluate the effects of spongy moth defoliation on blacklegged ticks, the primary vectors of Lyme disease and other tick-borne illnesses in the United States. The project aims to investigate how changes in ground-level temperature and humidity caused by spongy moth outbreaks may...
- Federal Grant Award Summary Banfieldbio Inc. received an $800,000 project grant from the USDA's National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310), awarded May 1, 2025, with completion targeted for September 30, 2028. The award supports continuation of prior USDA Small Business Innovation Research (SBIR) work on tick monitoring and surveillance, expanding to address cattle fever ticks, Asian longhorned ticks, and...
- The University of Rhode Island (URI) was awarded a $117,696 Cooperative Agreement by the U.S. Department of the Interior U.S. Geological Survey's Research and Data Collection program (CFDA 15.808) to develop frameworks for structured decision-making in tick and tick-borne disease management in New England. The key products and services to be delivered under this award include: Consolidating scientific knowledge on tick control and management into an accessible database for vector management...
- This National Science Foundation (NSF) Integrative Activities (IA) Program Project Grant award to Louisiana State University (LSU) provides $199,994 in funding from March 1, 2024 to February 28, 2026. The project aims to develop a family of natural product-based insect repellent compounds that are safer and more effective than commercial alternatives. Key activities include optimizing the chemical synthesis process for the parent compound nootkatone to significantly reduce production costs. This...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $417,845 to the University of Nebraska Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from August 1, 2025, through July 31, 2027. The award supports the development and adaptation of an innovative in vitro organotypic human skin model designed to enable tick feeding and study the transmission and colonization of Borrelia...
POLYMERIC MATRIX LOADED WITH TICK REPELLENT OR TOXIC COMPOSITIONS FOR INCORPORATION INTO FABRICS OR FOR GRANULAR DISPERSAL - PROJECT SUMMARY/ABSTRACT WITHIN THE US, TICKS TRANSMIT 18 HUMAN PATHOGENS, ONE OF THE MOST SERIOUS BEING LYME DISEASE, WITH AN ESTIMATED 476,000 CASES PER YEAR. CURRENT TICK MANAGEMENT AND HUMAN REPELLENT AND TOXIC PRODUCTS WERE DESIGNED EITHER WITH PROTECTION AGAINST TICKS AS AN "AFTER-THOUGHT" OR THROUGH THE USE OF A PYRETHROID INSECTICIDE TO WHICH TICKS ARE INCREASINGLY DEVELOPING RESISTANCE. THERE IS ALSO A CURRENT PUSH BY CONSUMERS TO USE NATURAL AND ORGANIC PEST CONTROL PRODUCTS. AS GLOBAL TEMPERATURES RISE, LEADING TO A HIGHER INCIDENCE OF TICK-BORNE DISEASES, THERE IS A CRITICAL NEED FOR IMPROVED TICK MANAGEMENT PRODUCTS. THIS PHASE II APPLICATION WILL BUILD ON THE DEVELOPMENT OF NOVEL POLYMERIC MICROPARTICLES AS CARRIERS OF NON-VOLATILE ACARICIDES BY BANFIELDBIO FOR THE DWFP AWARD ON "MURINE AUTODISSEMINATION FOR LONG-TERM, AREA-WIDE CONTROL OF TICKS". BASED ON ENCOURAGING PRELIMINARY EVIDENCE, WE PROPOSE TO ADAPT THE POLYMERIC MICROPARTICLES TO MANUFACTURE MICROPOROUS POLYMERIC GRANULES AND FIBERS THAT CAN BE FORMULATED TO RELEASE VOLATILE REPELLENTS AND TOXICANTS. FORMULATED GRANULES WOULD BE USED IN LANDSCAPE TREATMENTS TO KILL AND REPEL TICKS, AND THE FIBERS WOULD BE WOVEN INTO OUTERWEAR FABRICS TO PROTECT HUMANS FROM ACQUIRING AND BEING BITTEN BY TICKS. CANDIDATE ACTIVE INGREDIENTS ARE NOOTKATONE AND 2-UNDECANONE, WHICH COULD BE USED ALONE OR IN COMBINATION WITH EACH OTHER AND/OR PERMETHRIN. THE PROJECT WILL TARGET TWO SPECIES, BLACKLEGGED TICKS AND LONE STAR TICKS, BOTH OF WHICH ARE IMPORTANT VECTORS OF HUMAN DISEASE, AND WILL EMPLOY LABORATORY AND FIELD EXPERIMENTATION TO EXPLORE AND DEVELOP BOTH TYPES OF FORMULATION INTO NOVEL PROTOTYPE PRODUCTS. THE PROPOSED RESEARCH AND DEVELOPMENT WOULD CULMINATE IN FIVE POTENTIAL OUTCOMES: 1) A PROPRIETARY POLYMERIC MICROPOROUS GRANULAR COMPOSITION FORMULATED WITH ONE OR MORE REPELLENT AND/OR TOXIC COMPOUNDS, 2) A DEMONSTRATION THAT THE FORMULATED GRANULAR COMPOSITION IS EFFECTIVE AGAINST IMMATURE AND ADULT TICKS, AND READY FOR SCALE-UP, TESTING AND DEVELOPMENT AS A LANDSCAPE-LEVEL TICK PREVENTIVE TREATMENT, 3) FABRIC INCORPORATING PROPRIETARY POLYMERIC MICROPOROUS FILAMENTS FORMULATED WITH ONE OR MORE REPELLENT AND/OR TOXIC COMPOUNDS, 4) DEMONSTRATION THAT THE FABRIC FORMULATED WITH ONE OR MORE REPELLENT AND/OR TOXIC COMPOUNDS IS EFFECTIVE AGAINST IMMATURE AND ADULT TICKS, 5) FABRIC FORMULATED WITH ONE OR MORE REPELLENT AND/OR TOXIC COMPOUNDS MANUFACTURED INTO GAITERS, AND READY FOR TECHNOLOGY TRANSFER TO COMMERCIAL FABRIC PRODUCTION AND INCORPORATION INTO MULTIPLE TYPES OF OUTERWEAR CLOTHING. AS APPLICABLE, PATENT APPLICATIONS WILL BE FILED, THE RESULTS PUBLISHED IN PEER-REVIEWED JOURNALS, AND PATHWAYS TO OPERATIONAL IMPLEMENTATION AND COMMERCIALIZATION WILL BE IDENTIFIED AND EXPLOITED.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/13/25 | ||
| Not listed | $919.6k | 8/12/24 | ||
| Not listed | $927.4k | 8/24/23 | ||
| Not listed | $928.7k | 9/23/22 | ||
| Not listed | $928.7k | 9/23/22 |