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Project Grant R44AI147734
Award Date
8/14/20
Completion Date
7/31/22
Dollars Obligated
$3.3M
Overview
Activity
Transactions
4
Subawards
Federal Agency
National Institute of Allergy and Infectious Diseases
Awardee
Enrich Biosystems Inc. (M6XYEESK8AS8)
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Description
Update #1
SINGLE CLONE DISCOVERY USING AN IMAGE-BASED CELL ISOLATION PLATFORM
Posted 8/14/20, 12:00 AM
Mod #
Description
Reason For Modification
Federal Obligation
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Date
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Not listed
SINGLE CLONE DISCOVERY USING AN IMAGE-BASED CELL ISOLATION PLATFORM - ABSTRACT CHARACTERIZING BOTH FUNCTIONAL AND GENETIC HETEROGENEITY AMONG A POOL OF CELLS REMAINS A MAJOR SCIENTIFIC CHALLENGE IN IMMUNOLOGY, CANCER RESEARCH, NEUROBIOLOGY AND DEVELOPMENTAL BIOLOGY. ISOLATING CELLS WITH THE SAME PHENOTYPE IS KEY TO UNDERSTAND SUCH HETEROGENEITY. WE WOULD LIKE TO DEVELOP A NON-FLUIDIC, UNIQUE TECHNOLOGY, LCD AIDED SELECTION UNDER MICROSCOPE (LASUM, FIG.1) TO ADDRESS THIS NEED. DURING THE PHASE I OF THIS PROJECT, WE COMPLETED THE ALPHA VERSION OF PROTOTYPE DESIGN AND DEMONSTRATED ITS UTILITY IN THREE PROOF-OF-CONCEPT EXPERIMENTS: (A) BLOOD CELL REMOVAL; (B) PHAGE ENRICHMENT ON SINGLE BEADS; (C) ISOLATION OF TUMOR-KILLING IMMUNE CELL CLONES. WE WOULD LIKE TO CONTINUE OUR EFFORT TO BRING THIS TECHNOLOGY TO MARKET, WHICH WILL BE LOW-COST, HIGH THROUGHPUT, DEBRIS RESISTANT, IMAGE-BASED WITH OPERATION SIMPLICITY AS PREPARING A MICROSCOPE SLIDE OR WASHING A MICROTITER PLATE. BESIDES THE DEVICE, WE WILL UNIFY THE FRAGMENTATED CELL ISOLATION MARKET USING TWO ASSOCIATED KITS: ENRICH-LIVE AND ENRICH- SEQ. THE SUCCESSFUL COMMERCIALIZATION OF THIS DEVICE/KITS WILL ENABLE THOUSANDS OF CELL- BIOLOGY LABS AND HOSPITALS IN MANIPULATING SINGLE CELLS ON A COMPUTER SCREEN.
($69)
9/13/23
Not listed
SINGLE CLONE DISCOVERY USING AN IMAGE-BASED CELL ISOLATION PLATFORM - ABSTRACT CHARACTERIZING BOTH FUNCTIONAL AND GENETIC HETEROGENEITY AMONG A POOL OF CELLS REMAINS A MAJOR SCIENTIFIC CHALLENGE IN IMMUNOLOGY, CANCER RESEARCH, NEUROBIOLOGY AND DEVELOPMENTAL BIOLOGY. ISOLATING CELLS WITH THE SAME PHENOTYPE IS KEY TO UNDERSTAND SUCH HETEROGENEITY. WE WOULD LIKE TO DEVELOP A NON-FLUIDIC, UNIQUE TECHNOLOGY, LCD AIDED SELECTION UNDER MICROSCOPE (LASUM, FIG.1) TO ADDRESS THIS NEED. DURING THE PHASE I OF THIS PROJECT, WE COMPLETED THE ALPHA VERSION OF PROTOTYPE DESIGN AND DEMONSTRATED ITS UTILITY IN THREE PROOF-OF-CONCEPT EXPERIMENTS: (A) BLOOD CELL REMOVAL; (B) PHAGE ENRICHMENT ON SINGLE BEADS; (C) ISOLATION OF TUMOR-KILLING IMMUNE CELL CLONES. WE WOULD LIKE TO CONTINUE OUR EFFORT TO BRING THIS TECHNOLOGY TO MARKET, WHICH WILL BE LOW-COST, HIGH THROUGHPUT, DEBRIS RESISTANT, IMAGE-BASED WITH OPERATION SIMPLICITY AS PREPARING A MICROSCOPE SLIDE OR WASHING A MICROTITER PLATE. BESIDES THE DEVICE, WE WILL UNIFY THE FRAGMENTATED CELL ISOLATION MARKET USING TWO ASSOCIATED KITS: ENRICH-LIVE AND ENRICH- SEQ. THE SUCCESSFUL COMMERCIALIZATION OF THIS DEVICE/KITS WILL ENABLE THOUSANDS OF CELL- BIOLOGY LABS AND HOSPITALS IN MANIPULATING SINGLE CELLS ON A COMPUTER SCREEN.
$829.1k
7/19/21
Not listed
SINGLE CLONE DISCOVERY USING AN IMAGE-BASED CELL ISOLATION PLATFORM - ABSTRACT CHARACTERIZING BOTH FUNCTIONAL AND GENETIC HETEROGENEITY AMONG A POOL OF CELLS REMAINS A MAJOR SCIENTIFIC CHALLENGE IN IMMUNOLOGY, CANCER RESEARCH, NEUROBIOLOGY AND DEVELOPMENTAL BIOLOGY. ISOLATING CELLS WITH THE SAME PHENOTYPE IS KEY TO UNDERSTAND SUCH HETEROGENEITY. WE WOULD LIKE TO DEVELOP A NON-FLUIDIC, UNIQUE TECHNOLOGY, LCD AIDED SELECTION UNDER MICROSCOPE (LASUM, FIG.1) TO ADDRESS THIS NEED. DURING THE PHASE I OF THIS PROJECT, WE COMPLETED THE ALPHA VERSION OF PROTOTYPE DESIGN AND DEMONSTRATED ITS UTILITY IN THREE PROOF-OF-CONCEPT EXPERIMENTS: (A) BLOOD CELL REMOVAL; (B) PHAGE ENRICHMENT ON SINGLE BEADS; (C) ISOLATION OF TUMOR-KILLING IMMUNE CELL CLONES. WE WOULD LIKE TO CONTINUE OUR EFFORT TO BRING THIS TECHNOLOGY TO MARKET, WHICH WILL BE LOW-COST, HIGH THROUGHPUT, DEBRIS RESISTANT, IMAGE-BASED WITH OPERATION SIMPLICITY AS PREPARING A MICROSCOPE SLIDE OR WASHING A MICROTITER PLATE. BESIDES THE DEVICE, WE WILL UNIFY THE FRAGMENTATED CELL ISOLATION MARKET USING TWO ASSOCIATED KITS: ENRICH-LIVE AND ENRICH- SEQ. THE SUCCESSFUL COMMERCIALIZATION OF THIS DEVICE/KITS WILL ENABLE THOUSANDS OF CELL- BIOLOGY LABS AND HOSPITALS IN MANIPULATING SINGLE CELLS ON A COMPUTER SCREEN.
$829.1k
7/19/21
Not listed
SINGLE CLONE DISCOVERY USING AN IMAGE-BASED CELL ISOLATION PLATFORM
$846.9k
8/14/20