Project Grant R44AI143170

This $842,151 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of an improved, low-endotoxin E. coli strain for the production of biological products such as recombinant proteins and plasmid DNA. The awardee, Scarab Genomics LLC, a biotechnology company in Madison, Wisconsin, will use genetic engineering techniques to substantially lower the level of contaminating endotoxin...

This $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under the 93.350 CFDA program, supports the development of the Codomax EPI-MAX platform. This integrated omics and computational technology leverages cellular stress responses to enhance the production of difficult-to-express therapeutic proteins, with a focus on improving secretion and preventing aggregation in the Pichia pastoris expression system. The key products or services to be...

This $599,409 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support Opera Bioscience, Inc.'s development of a novel bacterial protein secretion platform for cost-effective production of recombinant proteins and growth factors for therapeutic applications. The project aims to create an optimized, safe production strain and define optimal growth conditions to maximize secreted...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a bioprocessing system to isolate and purify therapeutic antibodies directly from cell culture. The $999,998 award to Athem LLC, a minority-owned small business, will enable scaling up a novel nanoparticle-based purification media and an automated prototype system. The goal is to simplify the manufacturing of biologics, reduce...

Cornell University received a $100,000 Project Grant award from the National Science Foundation's Technology, Innovation, and Partnerships program to develop a cell-free biosensing platform integrating transmembrane proteins. The award period is from July 1, 2022 to December 31, 2022. Specifically, the university will utilize recent advances in biotechnology and bioelectronics to establish a process for rapidly assembling customized transmembrane proteins into a biomimetic sensing device without...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $350,000 in funding to Cisterna Biologics, Inc. to develop a novel process for producing ultra-pure mRNA. The key objectives are to optimize psychrophilic (cold-adapted) RNA polymerases and a proprietary purification technology to significantly reduce contaminants in mRNA production, improving safety and efficacy for...

This SBIR Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,248,994 to Opera Bioscience, Inc. to further develop an innovative bacterial protein secretion platform technology into a commercially viable, cost-effective protein expression system. The project aims to optimize industrial-scale manufacturing processes for producing multiple classes of recombinant proteins...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel in-line biomanufacturing process analytical technology tool. The $302,417 award to Physical Sciences Inc. (PSI), in collaboration with the University of Massachusetts Lowell (UML), aims to enable real-time monitoring of biomolecules in large-scale bioreactors for gene therapy manufacturing. The technology...