Project Grant R44AI142964

This Cooperative Agreement award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) provides $470,309 to Chromologic LLC to investigate the mechanisms by which an orally administered genetically modified probiotic can mitigate the hematopoietic and gastrointestinal acute radiation syndrome (H-ARS and GI-ARS) resulting from exposure to ionizing radiation. The project aims to develop an FDA-approved radiation injury mitigator that can be easily administered...

The Tiny Cargo Company received a $432,000 National Science Foundation Technology, Innovation, and Partnerships Project Grant to test the scalability of an exosome isolation technology for developing an orally administered radioprotective therapeutic. The goal is to establish proof-of-concept for a safe, orally delivered drug platform capable of transporting biologic and small molecule therapeutics to treat radiation damage and related diseases. The first year of the award will determine scaling...

This $294,660 project grant from the National Institutes of Health's National Institute of Environmental Health Sciences, under the NIEHS Hazardous Waste Worker Health and Safety Training program (CFDA 93.142), will support Radiation Emergency Services LLC to develop a prototype simulation game and training platform. The RadTeamSim-ROUTE simulation aims to address gaps in hands-on radiological field survey training by blending radiological dose modeling with gaming software. This will create...

The U.S. National Institutes of Health (NIH) awarded a 5-year, $593,823 Cooperative Agreement under the Trans-NIH Research Support program (CFDA 93.310) to Albert Einstein College of Medicine to develop a thrombopoietin (TPO) mimetic peptide (TPOM) as a medical countermeasure for gastrointestinal acute radiation syndrome (GI-ARS). The key objectives are to: 1) mitigate GI-ARS and determine the dose modification factor of TPOM; 2) elucidate the mechanisms of action of TPOM for radio-mitigation of...

The National Cancer Institute (NCI) awarded a $898,497 Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) to Radiopharmaceutical Imaging and Dosimetry, LLC to develop a cloud-based, customer-responsive dosimetry tool for alpha-particle emitting radiopharmaceutical therapies. The key objectives are to: 1) establish a library of microscale S-values and apportionment factors for dose-limiting tissues, 2) implement a macro-to-micro dosimetry methodology to enable...

The U.S. Department of Energy, through its Office of Science Financial Assistance Program (CFDA 81.049), awarded a $779,072.20 Project Grant to Northwestern University to conduct research on "Single Cell Level Elemental Signatures of Low Dose Radiation Exposures in Mammalian Model Systems." The project aims to advance understanding of the effects of low-dose radiation exposure on mammalian cells. The award period runs from September 1, 2024, to August 31, 2025. The project includes a...

Radiation Detection Technologies, Inc. received a $199,317 project grant award from the Department of Energy Office of Science on June 27, 2022 to commercialize the Micro Pocket Fission Detector (MPFD). The award will support Radiation Detection Technologies' efforts to develop and bring to market the MPFD, a handheld radiation detection device, through June 26, 2023. The Office of Science Financial Assistance Program (CFDA #81.049) aims to deliver scientific discoveries and tools that transform...

Radiation Monitoring Devices, Inc. was awarded a $199,977 Project Grant from the Department of Energy Office of Science under the Office of Science Financial Assistance Program (CFDA 81.049) to develop the PLATYPUS wireless multi-sensor platform for dry spent fuel cask monitoring. The platform will incorporate multiple sensors to remotely monitor conditions of dry cask storage systems for spent nuclear fuel. Dynasil Corporation of America is the parent organization of Radiation Monitoring...

This federal Project Grant award of $644,622 from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) aims to enhance radioligand therapy for prostate cancer through the development of biomarker and dosimetry-guided personalized treatment approaches. The key objectives are to: 1) develop a novel method for bone marrow dosimetry using macro/micro Monte Carlo modeling, 2) build predictive models to estimate absorbed radiation doses from pre-therapy PET...

The National Institutes of Health (NIH) awarded a $239,363 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. The grant aims to determine the radioprotective efficacy of dietary administration of highly radiation-resistant non-pathogenic fungi in the Drosophila model system. The research will evaluate if consumption of these fungal strains can increase resistance to acute radiation damage across...