Project Grant R44AI120617

The National Human Genome Research Institute (NHGRI) awarded a $457,920 Project Grant (CFDA #93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a deep reinforcement learning framework for haplotype assembly. Haplotype assembly is critical for understanding human population genetics and disease, as it reconstructs the combination of alleles on maternally and paternally inherited chromosome copies. The Broad Institute, a renowned biomedical and genomic research organization,...

The U.S. National Human Genome Research Institute (NHGRI) awarded a $1,696,968 Cooperative Agreement grant (CFDA 93.172 - Human Genome Research) to the University of California, Santa Cruz to develop novel computational methods and software tools for analyzing pangenomic data, with a focus on improving the accuracy and efficiency of variant calling and genotyping, particularly for complex structural variants. The grant, titled "Tools for Comprehensive Variant Characterization Using the...

The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...

This Project Grant award of $200,000 from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Cornell University to optimize the Genotype Representation Graph (GRG) data structure for efficient analysis of whole genome sequencing (WGS) data on modern parallel computing architectures. The research aims to develop tools and infrastructure to enable faster and more scalable processing of large genomic datasets, such as the UK Biobank, in order to...

This $1,645,076 Cooperative Agreement award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research (CFDA 93.172) program will develop advanced tools and resources to enable new ways to access and understand the human pangenome. The key products and services to be delivered include: Sequence alignment and population genetic analysis methods to rapidly search, compare, and interpret pangenome data, leveraging succinct data structures for scalable pangenome...

The National Human Genome Research Institute (NHGRI) awarded a $993,446 Project Grant under the Human Genome Research Federal Grant Program (CFDA 93.172) to the Sloan-Kettering Institute for Cancer Research. The 5-year grant, commencing on May 1, 2025, aims to develop statistical and machine learning approaches that connect human genetics data with single-cell omics data to improve the understanding of the genetic architecture underlying complex diseases. Key goals include decoding the...

Federal Project Grant Award Summary Boston Children's Hospital received a $130,680 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective July 1, 2025 through June 30, 2027. The award supports the development of computational technologies and statistical methods for single-cell functional genomics analysis. The research deliverables include: (1) deep learning computational frameworks to decode epigenetic...

This $138,428 project grant from the National Science Foundation's Computer and Information Science and Engineering program (CFDA 47.070) will support the development of computationally tractable structured hierarchical models to identify complex genetic associations hidden from current methods. The grantee, J. David Gladstone Institutes, will analyze genomic and clinical trait data using machine learning to build predictive models for individualized disease risk assessment and personalized...

The Regents of the University of Minnesota received a $362,340 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded August 19, 2025, with a completion date of July 31, 2029. The project delivers a novel genetic mapping methodology called CRI-SPA-MAP designed to systematically identify causal genes that shape complex multigenic traits. The research applies this methodology across three complementary experimental...

Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) for the period May 18, 2026 through April 30, 2028. The award supports research on cross-species analysis of regulatory function using synthetic regulatory genomics. The project will develop and apply the BIG-IN (Biomolecular In-place Genome INgineering) genome engineering...