Project Grant R44AG091903

Award Date 4/1/25
Completion Date 3/31/26
Dollars Obligated $500K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
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This $574,474 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports the development and preclinical testing of self-adjuvanting peptide nanofiber (PNF) vaccines targeting amyloid-beta (Aβ) and tau proteins for the treatment of Alzheimer's disease (AD) and frontotemporal dementia (FTD). The Washington University in St. Louis, the prime awardee, will lead this effort in collaboration with the University of Texas Medical Branch at Galveston as a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $431,750 to develop and validate a novel immuno-gene therapy targeting pathogenic tau conformations associated with Alzheimer's disease and related tauopathies. The project aims to use recombinant adeno-associated viruses (AAVs) to deliver a single-chain fragment variable (scFv) antibody called TNT2 that specifically binds to the phosphatase-activating domain (PAD) of pathogenic tau...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $431,750 to a partnership between Henry Ford Health and Michigan State University Health Sciences. The funding will support the development and evaluation of a novel immuno-gene therapy targeting oligomeric tau, a key driver of neurodegeneration in tauopathies like Alzheimer's disease. Specifically, the project aims to engineer a single-chain antibody fragment (scFv) derived from the anti-tau...
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