Project Grant R44AG085832
- This Project Grant award of $423,994 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University aims to characterize spatial variations in RNA isoform expression in relation to Alzheimer's disease (AD) pathology. The research will leverage single-nucleus cDNA, long-read RNA sequencing, and in situ sequencing to profile isoform expression at single-cell resolution in the inferior frontal gyrus, a brain region pertinent to AD. The study will identify cell-type...
- This Project Grant award from the National Institutes of Health's Aging Research program (CFDA 93.866) will support research to identify early transcriptional and pathological changes in brain regions vulnerable to Alzheimer's disease (AD). The $459,076 award, granted to Trustees of Boston University, will use single-nucleus RNA sequencing and targeted mass spectrometry to profile cell type-specific gene expression and tau/amyloid beta proteoforms in the transentorhinal cortex, entorhinal...
- This $500,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support Sxrna Technologies, Inc. in developing an organoid toolkit for Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The company aims to create a platform for identifying senescent cells in living tissue, which can provide insights into the aging process and enable high-throughput drug screening in complex 3D tissue models. Specifically, the grant will fund...
- This $2,683,965 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development and optimization of an "all-human cellular system" or "brain-chip" to study the cellular mechanisms underlying vulnerability to Alzheimer's disease (AD). The grant enables researchers at Brigham & Women's Hospital Inc. to leverage...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,018,778 to The Lieber Institute for Brain Development (LIBD) to generate spatially-resolved, transcriptome-wide gene expression profiles of the human dentate gyrus across the lifespan. The project aims to characterize developmental and age-related changes in gene expression within specific subregions of the hippocampus, a critical brain structure involved in learning, memory, and...
- This $1,221,276 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the "In Vivo Single-Cell Analysis of Alzheimer's Disease-Associated Regulatory Elements" research project at the University of North Carolina at Chapel Hill. The project aims to develop a novel genomic platform called Single-Cell Massively Parallel Reporter Assays (SCMPRA) to investigate how Alzheimer's disease-associated regulatory elements orchestrate gene expression...
- This $209,148 federal Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to develop the first lifespan-matched, comparative single-cell spatial transcriptomic atlas of the prefrontal cortex and hippocampus in humans and rhesus macaques. Using the cutting-edge Spatial Molecular Imager (SMI) platform, the project will generate high-resolution, single-cell gene expression profiles across different life stages - young, adult, and aged -...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute in Seattle, WA. The award, spanning September 2024 to September 2027, aims to develop two "exa-scale" (extremely high-throughput) tissue readout methods to transform the study of the brain. The first method will enable highly multiplexed molecular mapping of individual proteins across entire brains at the...
- This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...
SPATIAL SINGLE CELL ANALYSIS OF THE HUMAN ALZHEIMER'S DISEASE BRAIN - SUMMARY THE MAJOR GOAL OF THIS PROJECT IS TO STUDY HUMAN ALZHEIMER'S DISEASE (AD) BRAINS USING THE SPATIAL GENOMICS GENEPS INSTRUMENT FOR AUTOMATED LARGE SCALE GENE EXPRESSION ANALYSIS AT SINGLE CELL RESOLUTION. AT SPATIAL GENOMICS, WE ARE COMMERCIALIZING THE SEQUENTIAL FLUORESCENCE IN SITU HYBRIDIZATION (SEQFISH) TECHNOLOGY (ENG ET AL, 2019) THAT ALLOWS THOUSANDS OF GENES TO BE IMAGED DIRECTLY IN BRAIN SAMPLES. WE HAVE EXPERIENCE WORKING WITH HUMAN BRAINS WITH OUR SEQFISH TECHNOLOGY AND WILL HONE THE TECHNOLOGY FOR USE IN HUMAN BRAINS. USING THE SEQFISH METHOD, WE WILL IDENTIFY CHANGES IN CELL TYPES, SPATIAL ORGANIZATION OF GROUPS OF CELLS, AND SIGNALING INTERACTIONS BETWEEN NEIGHBORING CELLS IN THE HUMAN AD BRAIN.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/9/24 | ||
| Not listed | $1.2m | 9/20/23 |