Project Grant R44AG063635

This $1,569,990 project grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will conduct a randomized, double-blind, placebo-controlled trial to compare the effects of lysophosphatidylcholine-enriched docosahexaenoic acid (LPC-DHA) and triglyceride-esterified DHA (TAG-DHA) supplementation on cerebrospinal fluid DHA levels, neurodegenerative biomarkers, and neurotrophic factors in elderly adults with subjective cognitive decline. The University of Cincinnati will...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,399,431 to Boston University Medical Campus to develop a digital cognitive health resource for the early detection and prevention of Alzheimer's disease and related dementias. The project will leverage the Boston University Alzheimer's Disease Research Center cohort to collect longitudinal digital cognitive phenotypes using technologies like digital recorders, pens, and smartphone...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) totaling $212,816 will investigate the use of plasma-based neuronal insulin signaling exosomes as a potential biomarker for cognitive impairment in individuals with diabetes mellitus. The research will leverage data from the ACCORD-MIND study to examine whether impaired neuronal insulin signaling precedes brain volume loss and cognitive decline in 200 male and female study participants with varying...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Emory University to evaluate the Visuospatial Memory Eye-Tracking Test (VISMET) as a tool for detecting early cognitive changes associated with Alzheimer's disease. The $786,440 grant will fund a two-year project to replicate prior findings demonstrating VISMET's ability to predict global cognitive performance, as well as its capacity to detect preclinical Alzheimer's disease and...

This $2,202,905 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to leverage the Electronic Self-Administered Gerocognitive Examination (ESAGE) and EHR data, combined with machine learning techniques, to develop an accessible and accurate tool for early detection and monitoring of cognitive impairment, including in underserved populations. The key products and services to be delivered under this 5-year grant include: 1) Developing behavioral...

This Project Grant award of $3,223,259 from the National Institute on Aging (CFDA 93.866 Aging Research) supports the development and evaluation of a deep learning algorithm, DECIPHER-AI, to improve the detection of cognitive impairment (CI) due to Alzheimer's disease and related dementias (ADRD) using electronic health record (EHR) data. The award will fund work across three healthcare institutions - Massachusetts General Brigham, University of Wisconsin-Madison, and University of Texas...

This $2,724,191 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) will support an initiative to improve diagnosis of Alzheimer's disease and related neurodegenerative dementias in primary care settings. The University of California, San Francisco will lead the 5-year project, partnering with primary care practices that serve medically underserved communities to assess approximately 750 patients using a comprehensive diagnostic toolkit. The...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $155,000 to Wake Forest University Health Sciences (WFUHS) to identify microRNA (miRNA) biomarkers that could detect early cognitive impairment and Alzheimer's disease progression. The key objectives are to: 1) Identify circulating miRNA biomarkers associated with distinct stages of Alzheimer's disease, and 2) Determine potential miRNA regulatory targets underlying early cognitive decline and...

This $446,619 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project led by the University of North Carolina at Chapel Hill to develop and evaluate a novel olfactory-based approach for measuring memory function and assessing the risks of Alzheimer's disease and related dementias in diverse global populations. The key products and services to be delivered under this 3-year award include: 1) Fielding an olfactory memory assessment...

The National Institute on Aging (NIA) awarded a $885,006 Project Grant under the Aging Research program (CFDA 93.866) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Inc., to develop a smartphone-based point-of-care diagnostic system capable of detecting Alzheimer's disease (AD) biomarkers in blood plasma within 30 minutes. The system will leverage microfluidics, nanotechnology, optical sensing, and deep learning to detect levels of amyloid-beta,...