Project Grant R44AA022266

This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a non-invasive liquid biopsy screening tool for detecting the causes and consequences of preterm birth. The $717,871 award, granted to the Magee-Womens Research Institute and Foundation, will fund the development of epigenomic analytical methods to predict the clinical trajectories of...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $594,784 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Yale University to conduct a multi-omic study of brains from 341 individuals to investigate the molecular pathology of alcohol use disorder (AUD). The central goal is to identify novel lasting transcriptomic and epigenetic changes in biological pathways that could serve as biomarkers and therapeutic targets for AUD. The project will analyze...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $499,987 Project Grant under CFDA 93.273 (Alcohol Research Programs) to CFD Research Corporation to develop a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids. The goal is to create an automated system capable of maturing, maintaining, and assaying over 100 organoids in culture to provide a robust and genetically diverse platform for screening potential therapeutic drug candidates...

This Project Grant award, valued at $265,510.00 and awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to evaluate the feasibility and efficacy of Trigeminal Nerve Stimulation (TNS) as a treatment for Prenatal Alcohol Exposure (PAE), a severe neurodevelopmental disorder. The proposed research comprises two phases: an initial R61 pilot study to assess the feasibility of using TNS in children...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $412,125 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Research Foundation For The State University Of New York to study the impact of prenatal alcohol and methadone exposure on the regulation of dopamine signaling and synaptic plasticity in the basolateral amygdala. The two-year project aims to determine how the combined exposure to prenatal alcohol and methadone alters social and non-social...

This $231,364 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund the development and feasibility testing of the "Families Moving Forward (FMF) Bridges" early intervention program. The FMF Bridges intervention is designed to support infants and toddlers aged 6-36 months who were prenatally exposed to alcohol or have a Fetal Alcohol Spectrum Disorder (FASD), as well as their caregivers. The...

The U.S. Department of Health & Human Services (HHS), through the Maternal and Child Health Federal Consolidated Programs (CFDA 93.110), awarded a $1,899,958 Project Grant to Boston Medical Center Corporation (BMC) to support the Safest Choice National Learning Collaborative. This 5-year program, which began on September 1, 2024, aims to improve the ability of primary care providers and their teams to screen for alcohol use during pregnancy, provide brief interventions to prevent prenatal...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $147,486.00 to Emory University to conduct research on how defects in maternal epigenetic reprogramming by the enzyme LSD1/KDM1A contribute to inherited phenotypes. The research aims to determine if compromised maternal LSD1 reprogramming at fertilization leads directly to phenotypes in the...

This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to develop treatments for mental deficiencies caused by fetal exposure to alcohol. The $725,192 award to The Leland Stanford Junior University aims to characterize the dose-response relationship and maximum tolerated oral dose of the drug vinpocetine for improving neuronal plasticity in animal models of...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...