Project Grant R43RR031935

The National Science Foundation (NSF) Division of Chemistry awarded a $480,000 Project Grant to Virginia Commonwealth University (VCU) to improve the separation of complex biological samples by exploring the use of mixed-mode gradient stationary phases for liquid chromatography (LC). This 3-year project, funded under the Mathematical and Physical Sciences program (CFDA 47.049), aims to develop new approaches to strategically modify particle-packed silica columns with functionalized...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $1,250,000 in funding to Zaiput Flow Technologies LLC, a small business manufacturer based in Waltham, Massachusetts. The award supports the further development of an innovative continuous crystallization device for pharmaceutical manufacturing. The key objectives are to create a scalable, cost-effective, and consistent crystallization process that...

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

This National Science Foundation (NSF) Cooperative Agreement award under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $997,735.00 to Chromatir Technologies, LLC to develop microtextured color-shifting security films for protection against counterfeiting of documents and currency. The project aims to create optical security features that leverage interference-based color generation to produce visually distinctive and color-changing appearances. The key...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, provides $329,272 to Capienda Biotech, LLC to develop a high-throughput kinetic system for small-molecule drug discovery. The goal is to create an innovative instrument that can rapidly characterize the binding kinetics of compounds targeting human cyclin-dependent kinases, which are important oncology targets. This will help medicinal chemists identify drug candidates...

This $339,300 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports Triangle Biotechnology's development of a nanodroplet-enhanced sonication technology called ChromExtract. The goal is to enable high-quality, high-yield, and consistent chromatin extraction from formalin-fixed, paraffin-embedded (FFPE) tissue samples for downstream chromatin profiling and accessibility analyses. The...

This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) will develop a novel membrane separation technology to address the energy-efficient separation of small molecules from industrial process streams for a range of industries. The $275,000 award to Avanpore LLC, a for-profit limited liability company located in Woburn, MA, will run from October 1, 2024 to March 31, 2025. The project aims to create functionalized...

This $306,872 Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) supports the development of a 3D printed integrated sample preparation and chromatography platform for proteomics research at Millennial Materials & Devices Inc., a small disadvantaged business located in Stony Brook, New York. The project aims to fabricate customized 3D printed carbon microbead stationary phase materials and additive manufacturing tools to create an integrated...

This $902,504 cooperative agreement from the National Science Foundation Division of Industrial Innovation under the Engineering program (CFDA 47.041) supports the development of a scalable downstream purification process for gene therapy vectors by Isolere Bio, Inc. of Durham, North Carolina. The non-chromatographic method seeks to address current inefficiencies that lead to single digit yields by utilizing a polypeptide-based reagent combining affinity capture with phase separation and...